2024年12月25日 · IL6R (Interleukin 6 Receptor) is a Protein Coding gene. Diseases associated with IL6R include Hyper-Ige Syndrome 5, Autosomal Recessive, With Recurrent Infections and Soluble Interleukin-6 Receptor, Serum Level Of, Quantitative Trait Locus. Among its related pathways are TGF-Beta Pathway and MIF Mediated Glucocorticoid Regulation.

Interleukin 6 (IL6) is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in immune response. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer.

2018年1月1日 · The interleukin-6 receptor (IL-6R) is a type I transmembrane protein that was cloned and described in 1988 (Yamasaki et al. 1988). It serves as the non-signaling alpha-receptor of the multifunctional cytokine IL-6 and is expressed in a cell-type-specific manner.

2025年2月11日 · IL6Ralpha function in myeloid cells modulates the inflammatory response during irritant contact dermatitis. Repopulating Microglia Promote Brain Repair in an IL-6-Dependent Manner. Il6ra deletion in smooth muscle cells resulted in increased severity of both Schistosoma- and hypoxia-induced Pulmonary Hypertension.

白介素6 （IL-6）属于多效细胞因子，可促进T细胞群体扩增和活化以及B细胞分化，调节急性期反应。 人们已知心理压力会诱导内分泌IL-6，并已在大鼠，小鼠和人类中被证明。 但 急性应激 诱导的IL-6来源基础尚不清楚，机体在应激下能量的产生与IL-6的联系尚未明确，IL-6与代谢和炎症之间的关系也有待研究。 因此，本文的研究对应激条件下的机体对于外界的反应以及能量代谢具有深远意义。 文章来源： doi.org/10.1016/j.cell. 作者使用小鼠模型证明IL-6是仅在急性应激时可诱导 …

2014年3月30日 · Il6ra Δmyel mice were resistant to IL-4-mediated alternative polarization of macrophages and exhibited enhanced susceptibility to lipopolysaccharide (LPS)-induced endotoxemia. Our results...

2024年6月13日 · 敲低Il6ra显著延长肿瘤恶病质小鼠寿命，缓解其体重降低水平，提高摄食、摄水量（图3c-h）；研究人员还引入另一种肿瘤恶病质模型——胰腺导管腺癌（PDAC）模型，得到相似结果（图4a-h），且AP、NTS、PBN、PVN、BNST与CeA内Fos阳性细胞数量显著减少。

Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation leads to the regulation of the immune response, acute-phase reactions and hematopoiesis.

2024年12月9日 · Title: Diabetic Müller-Glial-Cell-Specific Il6ra Knockout Mice Exhibit Accelerated Retinal Functional Decline and Thinning of the Inner Nuclear Layer. Interleukin 6 receptor is not directly involved in regulation of body weight in diet-induced obesity with …

IL-6R alpha 是 IL-6R 的 α 亚基，也被其他白细胞介素受体共享。 IL-6R alpha 可作为 IL-6 激动剂，参与包括 JAK /STAT、MAPK 和 Akt 在内的信号通路。 IL-6R alpha 由 468 个氨基酸 (M1-R468) 组成，存在两个 N 端纤维连接蛋白 III 型结构域 (113-217 a.a, 218-316 a.a) 和可溶性形式 (1-365 a.a)。 可溶性 IL-6R (sIL-6R) 可结合 IL-6 和二聚体化的 gp130 实现反式信号传导，并具有在特定免疫组织表达的特异性。