2019年11月19日 · Nature Immunology - The cytokine IL-7 plays essential roles in lymphocyte development. In their Review, Barata, Durum and Seddon describe IL-7’s key homeostatic functions and how its...

Interleukin-7 (IL-7) is a multipotent cytokine that maintains the homeostasis of the immune system. IL-7 plays a vital role in T-cell development, proliferation, and differentiation, as well as in B cell maturation through the activation of the IL-7 receptor (IL-7R).

IL-7 contributes to T cell lymphopoiesis and survival. When T cells encounter antigens, IL-7 can boost T cell immune responses to fight against pathogens, including rescuing T cells from apoptosis, promoting naive T cells to differentiate into effector T …

2021年12月2日 · IL-7 contributes to host defense by regulating the development and homeostasis of immune cells, including T lymphocytes, B lymphocytes, and natural killer (NK) cells. Clinical trials of recombinant IL-7 have demonstrated safety and potent immune reconstitution effects.

IL-7 as an immunotherapy agent has been examined in many pre-clinical animal studies and more recently in human clinical trials for various malignancies and during HIV infection. [13][21] Recombinant IL-7 has been safely administered to patients in several phase I and II clinical trials.

2023年11月29日 · These data demonstrate that intratumorally administered IL-7–CBD combined with CBD–IL-12 could boost systemic antitumoral immune response and inhibit pulmonary metastasis and could promote tumor-specific anamnestic response, especially tumor-specific CD8 + T cells, and prevent tumor regrowth.

2021年12月2日 · IL-7 contributes to host defense by regulating the development and homeostasis of immune cells, including T lymphocytes, B lymphocytes, and natural killer (NK) cells. Clinical trials of recombinant IL-7 have demonstrated safety and potent immune reconstitution effects.

We investigated the role of IL-7 in the development and onset of AA in the C3H/HeJ mouse model and found that IL-7 enhances the cytotoxic T cell type 1 (Tc1) immune response in C3H/HeJ mice. We demonstrated that blockade of IL-7Rα reduces the number of alopecic T cells yet relatively spares regulatory T cells (T regs ), leading to the reversal ...

2011年4月21日 · In animals, IL-7 therapy enhances the effectiveness of adoptive immunotherapy for cancer, enhances vaccine responses and enhances viral clearance in the setting of acute and chronic infections.

2021年12月10日 · Interleukin-7 (IL-7) is produced by stromal cells, keratinocytes, and epithelial cells in host tissues or tumors and exerts a wide range of immune effects mediated by the IL-7 receptor (IL-7R). IL-7 is primarily involved in regulating the development of B cells, T cells, natural killer cells, and de …