在新选项卡中打开链接
  1. Copilot 答案
    Wikipedia
    https://en.wikipedia.org › wiki

    Interleukin 8 - Wikipedia

    Function

    IL-8, also known as monocyte-derived neutrophil chemotactic factor (MDNCF), has two primary functions. It … 展开

    IL-8 mediated chemotaxis of the neutrophil

    IL-8 is the primary cytokine involved in the recruitment of neutrophils to the site of damage or infection; in a process called chemotaxis. A number of variables are essential for the successful chemotaxis of neutrophils, inclu… 展开

    代号IL8; CXCL8; GCP-1; GCP1; LECT; LUCT; LYNAP; MDNCF; MONAP; NAF; NAP-1; NAP1
    扩展标识遗传学：146930 同源基因：47937 ChEMBL: 2157 GeneCards: IL8 Gene
    Target cells

    While neutrophil granulocytes are the primary target cells of IL-8, there are a relatively wide range of cells (endothelial cells, macrophages, mast cells, and keratinocytes) that respond to this chemokine. The … 展开

    Clinical significance

    Interleukin-8 is a key mediator associated with inflammation where it plays a key role in neutrophil recruitment and neutrophil degranulation. As an example, it has been cited as a proinflammatory mediator in gingivitis… 展开

    Modulators of CXCL8

    The production and release of CXCL8 (IL-8) can be influenced by multiple factors that regulate its expression and levels. Several cytokines and biochemical substances act as inducers of IL-8, including IL-1α, IL-1β, IL-7, IL-17, IL-22… 展开

    Regulation of CXCL8 expression

    The CXCL8 gene is located on chromosome 4q13-21 and consists of four exons and three introns, featuring a unique CAT- and TATA-like structure. The proximal promoter region, containing approximately 200 nucleotides withi… 展开

    Nomenclature

    IL-8 was renamed CXCL8 by the Chemokine Nomenclature Subcommittee of the International Union of Immunological Societies,. Its approved HUGO gene symbol is CXCL8. Its receptors were similarly renamed: … 展开

    CC-BY-SA 许可证中的维基百科文本