白细胞介素-8 （英語： Interleukin-8，简称为 白介素-8 或 IL-8，亦称为趋化因子 CXCL8）是 巨噬细胞 和 上皮细胞 等分泌的 细胞因子 [1]。 白细胞介素-8结合趨化因子受体白细胞介素-8受体α (IL8RA, 又叫 CXCR1)和白细胞介素-8受体β (IL8RB, 又叫 CXCR2)而对嗜中性粒细胞 (neutrophils)有细胞趋化作用而实现其对炎症反应的调节 [2][1]。 白细胞介素-8还有很强的促血管生成作用。 白细胞介素-8在 小支气管炎 [3] 和 囊性纤维化 [4] 的发病中起重要作用。 白细胞介 …

Interleukin 8 receptor, alpha is a chemokine receptor. This name and the corresponding gene symbol IL8RA have been replaced by the HGNC approved name C-X-C motif chemokine receptor 1 and the approved symbol CXCR1. It has also been designated as CD181 (cluster of differentiation 181).

白细胞介素-8，英文简称为 IL -8，是 趋化因子 家族的一种 细胞因子，在参与和调节人类生殖生理和 病理过程 的作用已得到肯定，其作用机制之一就是与其 特异性 受体结合而发挥作用。 已经发现了38种 白细胞介素，按照其发现顺序给予IL序号，分别命名为IL-1---IL-38。 它们功能复杂，成网络，复杂重叠。 1986年Kownatzki等首先证实了 单核细胞 可产生一种 中性粒细胞 趋化因子。

2024年12月24日 · Knockout studies in mice suggested that this protein inhibits embryonic oligodendrocyte precursor migration in developing spinal cord. This gene, IL8RB, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. [provided by RefSeq, Jul 2008]

Two human IL-8 receptors, IL8RA and IL8RB, are known from eDNA cloning; IL8RA is a promiscuous receptor for at least two other related ligands, GROa and NAP-2. We now report cloning of the...

2005年3月17日 · In order to evaluate the role of the IL8RA gene in the pathogenesis of COPD and asthma, we screened the coding region of IL8RA for mutations by means of single-strand conformation polymorphism...

2006年9月1日 · Interleukin 8 (IL8) is a potent proinflammatory cytokine that interacts with its receptors, IL8RA and IL8RB. We investigated the genetic polymorphisms in IL8, IL8RA, and IL8RB for any...

2023年3月24日 · 白细胞介素-8 (白介素-8, Interleukin-8, IL-8), 又称为 趋化因子 CXCL8是巨噬细胞和上皮细胞等分泌的细胞因子。 白细胞介素-8结合趋化因子受体白细胞介素-8受体α (IL8RA, 又叫CXCR1)和白细胞介素-8受体β (IL8RB, 又叫CXCR2)而对 中性粒细胞 有细胞趋化作用而实现其对炎症反应的调节。 白细胞介素-8还有很强的促血管生成作用。 白细胞介素-8在小支气管炎和 囊性纤维化 的发病中起重要作用。 白细胞介素-8 (白介素-8, Interleukin-8, IL-8)主要由单核－巨噬细 …

Interleukin-8 (IL-8) is the prototype for a family of at least eight neutrophil chemoattractants whose genes map to human chromosome 4q13-q21. Two human IL-8 receptors, IL8RA and IL8RB, are known from cDNA cloning; IL8RA is a promiscuous receptor for at least two other related ligands, GRO alpha and …

Interleukin-8 is a chemokine with a potent neutrophil chemoatractant activity. In humans, two different cDNAs encoding human IL8 receptors designated IL8RA and IL8RB have been cloned. IL8RA binds IL8, while IL8RB binds IL8 as well as other α-chemokines. Both human IL8Rs are encoded by two genes physically linked on chromosome 2.