Enhanced CAR-T activity against established tumors by ... - Nature
2020年11月19日 · Recently, we 20, 21, 22, 23 and others 24, 25 have shown that antigen-specific IL9-secreting (CD4 + Th9 or CD8 + Tc9) T cells are distinct subsets with stronger antitumor efficacy in murine...
IL-9 and IL-9-producing cells in tumor immunity - PubMed
2020年3月30日 · Since T-helper 9 (Th9) cell-derived IL-9 was verified to play a powerful antitumor role in solid tumors, an increasing number of researchers have started to pay attention to the role of IL-9-skewed CD8 + T (Tc9) cells, mast cells and Vδ2 T cell-derived IL-9 in tumor immunity. Here, we review recent studies on IL-9 and several kinds of IL-9 ...
Tumor-specific IL-9–producing CD8 - PubMed Central (PMC)
Our laboratory has identified a critical role of IL-9 in promoting endogenous tumor-specific cytotoxic T lymphocyte response. In this study, we found that differentiation of CD8+ T cells under T helper 9-polarizing conditions induces the development ...
Tumor-specific IL-9–producing CD8 - PNAS
2014年1月27日 · Our laboratory has identified a critical role of IL-9 in promoting endogenous tumor-specific cytotoxic T lymphocyte response. In this study, we found that differentiation of CD8 + T cells under T helper 9-polarizing conditions induces the development of an IL-9–producing less cytolytic IL-9–skewed CD8 + T (Tc9) cell subset.
IL-9-producing T cells: potential players in allergy and cancer - Nature
2020年8月12日 · IL-9-producing CD4 + T cells have been considered to represent a distinct T helper cell (T H cell) subset owing to their unique developmental programme in vitro, their expression of distinct...
Targeting the IL-9 pathway in cancer immunotherapy - PMC
IL-9 not only bolsters CD4 + CD8 + double-positive T cells survival by enhancing apoptotic resistance and proliferation of these T cells, but also enhances cytotoxic properties of activated CD4 + CD8 + T cells via secreting high levels of Granzyme B and Perforin .
Functional diversity and regulation of IL-9-producing T cells in …
2024年12月1日 · Depletion of either CD8 + or CD4 + T cells abolished the benefits of IL-9 loss to tumor control. Adoptive transfer experiments showed that T cells from tumor-rejecting IL9-deficient mice retained their effector competency in wild-type animals.
Because cytokine-priming signals direct CD8+ T cells to acquire unique profiles that affect their ability to mediate specific immune responses, here we generated IL-9–skewed CD8+ T (Tc9) cells by priming with Th9-polarized condition. Compared with type-I CD8+ cytotoxic T (Tc1) cells, Tc9 secreted different cytokines and were
IL-9 signaling redirects CAR T cell fate toward CD8+ memory
2025年2月4日 · Trajectory and RNA velocity analyses of single-cell RNA sequencing data reveal that IL-9 signaling alters CAR T cell differentiation under antigen stress away from dysfunction, favoring a multipotent transition toward CD8+ cell memory and effector states, and promoting a CD4+ cell proliferative state.
Tumor-specific IL-9-producing CD8+ Tc9 cells are superior ... - PubMed
2014年2月11日 · Because cytokine-priming signals direct CD8 (+) T cells to acquire unique profiles that affect their ability to mediate specific immune responses, here we generated IL-9-skewed CD8 (+) T (Tc9) cells by priming with Th9-polarized condition.