Significance of integrin-linked kinase (ILK) in tumorigenesis and …
Integrin-linked kinase (ILK), which is an ankyrin repeat-containing serine/threonine protein kinase, interacts with integrin β1 and the β3 cytoplasmic domain and phosphorylates integrin β1. ILK …
c-Jun N-terminal kinase is involved in the regulation of ... - PubMed
Our results demonstrated that ILK promoted proliferation and suppressed apoptosis via repressing phosphorylations of the JNK signal pathway in human retinoblastoma cells. This …
Integrin-linked kinase: both Jekyll and Hyde in rhabdomyosarcoma
2009年6月1日 · The authors provide compelling evidence of the Jekyll and Hyde nature of ILK: its tumor-suppressive function in ERMS and its oncogenic role in ARMS. A key issue, however, is …
JNK1 determines the oncogenic or tumor-suppressive activity of …
2009年6月1日 · We found that ILK was pro-oncogenic in ARMS and tumor suppressive in ERMS in vitro and in vivo. The tumor-suppressive function of ILK relied on the regulation of JNK1: …
ILK Signaling | GeneGlobe - Qiagen
Integrin linked kinase (ILK) is an intracellular protein whose main function is to connect integrins to the cytoskeleton. Different domains of ILK interact with different proteins. For example, the C …
Oncogenic ILK, tumor suppression and all that JNK - PubMed
2009年12月15日 · This review discusses the complex roles of ILK in tumorigenesis, and offers arguments to harness ILK and JNK signaling as novel targets for anti-cancer therapy.
Involvement of ILK/ERK1/2 and ILK/p38 pathways in mediating …
The ILK, ERK1/2 and p38 signals are significantly up-regulated by MNT, whereas the JNK activity is undetectable by Western blot. The MG63 cell morphology, proliferation and differentiation …
整合素连接激酶（ILK）基因 | MCE - MCE-生物活性分子大师
该基因编码一种具有激酶样结构域和四个锚蛋白样重复序列的蛋白质。 编码的蛋白质在细胞膜上与 β 整合素的细胞质结构域结合，在此处调节整合素介导的信号转导。 这种蛋白质的活性在上皮 …
ILK, PINCH and parvin: the tIPP of integrin signalling
2005年12月21日 · Integrin-linked kinase (ILK), PINCH and parvin form a ternary complex (the IPP complex) that binds to ECM-ligated integrins. This complex regulates signalling pathways and...
Integrin-linked kinase: both Jekyll and Hyde in rhabdomyosarcoma
2009年5月26日 · The authors provide compelling evidence of the Jekyll and Hyde nature of ILK: its tumor-suppressive function in ERMS and its oncogenic role in ARMS. A key issue, …