Imipenem (trade name Primaxin among others) is a synthetic β-lactam antibiotic belonging to the carbapenems chemical class. developed by Merck scientists Burton Christensen, William Leanza, and Kenneth Wildonger in the mid-1970s. [1] .

2023年9月7日 · Imipenem and cilastatin is an antibiotic that is used in adults and children to treat bacterial infections of the heart, lungs, bladder, kidneys, skin, blood, bones, joints, stomach, or female reproductive organs. Imipenem and cilastatin may also be used for purposes not listed in this medication guide.

Imipenem is a carbapenem antibiotic normally administered with cilastatin to treat a variety of infections. Imipenem is a semisynthetic thienamycin that has a wide spectrum of antibacterial activity against gram-negative and gram-positive aerobic and anaerobic bacteria, including many multiresistant strains.

Imipenem/cilastatin/relebactam, a relatively newer antibiotic, combines imipenem, cilastatin, and relebactam. Imipenem is a bactericidal carbapenem known for binding and inhibiting penicillin-binding proteins (PBP 1 B and PBP 2) in Enterobacteriaceae and P.-aeruginosa inhibits bacterial cell wall synthesis [22, 23].

亚胺培南，是一种医学药品，临床主要用于革兰阳性菌、阴性菌、厌氧菌所致的呼吸道感染、胆道感染、泌尿系统和腹腔感染、皮肤软组织、骨和关节、妇科感染等。

Imipenem is the first of a new class of β-lactam antibiotics, the carbapenems, to be released for clinical use. It has the broadest antibacterial activity of all antibiotics available for systemic use in humans.

Imipenem/cilastatin/relebactam (Recarbrio™) is an intravenously administered combination of the carbapenem imipenem, the renal dehydropeptidase-I inhibitor cilastatin, and the novel β-lactamase inhibitor relebactam.

PRIMAXIN for intravenous use is indicated for the treatment of lower respiratory tract infections caused by susceptible strains of Staphylococcus aureus (penicillinase-producing isolates),...

Imipenem is a semi-synthetic derivative of thienamycin, a β-lactam produced by Streptomyces cattleya, with very broad in vitro activity both against aerobic and anaerobic enteric bacteria, including most β-lactamase-producing strains.

Imipenem, or N-formimidoylthienamycin, is derived from thienamycin, a natural product of the soil organism Strepto myces cattleya. The N-formimidoyl side chain of imipenem enhances the chemical stability of thienamycin (Fig. Imipenem is the first …