2023年9月19日 · Immunoglobulin M: Your body makes IgM antibodies when you are first infected with new bacteria or other germs. They are your body's first line of defense against infections.

2022年12月15日 · Immunoglobulin M antibodies (IgM) are our first-line defense against a broad range of infections. They are often measured to help diagnose different conditions, such as infections, immunodeficiency, autoimmune disease, and certain types of cancer.

Immunoglobulin M (IgM) is the largest of several isotypes of antibodies (also known as immunoglobulin) that are produced by vertebrates. IgM is the first antibody to appear in the response to initial exposure to an antigen; [1] [2] causing it to …

2021年12月20日 · Immunoglobulin M is the largest and the first produced antibody which helps in the prevention or fighting of any new antigens or microbes in the body. It is predominantly found in the blood and the lymph fluid.

In normal serum, about 5% is IgM. Elevations of IgM may be due to polyclonal immunoglobulin production. Monoclonal elevations of IgM occur in macroglobulinemia. Monoclonal gammopathies of all types may lead to a spike in the gamma globulin zone seen on …

2022年12月19日 · IgM immunoglobulins are produced by plasma cells as part of the body's adaptive humoral immune response against a foreign pathogen. Resting mature yet naive, B lymphocytes express IgM as a transmembrane antigen receptor that functions as part of the B-cell receptor (BCR).

2024年1月23日 · The immunoglobulin M (IgM) is the largest antibody characterized by the µ heavy chain. Immunoglobulin M is the third most common serum Ig and exists in two forms: a pentamer comprising approximately 10% of normal human serum Ig content and a membrane-bound monomer expressed on the surface of B lymphocytes for antigen recognition.