2024年12月25日 · INF2 (Inverted Formin 2) is a Protein Coding gene. Diseases associated with INF2 include Charcot-Marie-Tooth Disease, Dominant Intermediate E and Focal Segmental Glomerulosclerosis 5. Among its related pathways are Nephrotic syndrome and Primary focal segmental glomerulosclerosis (FSGS).

INF2 accelerates actin nucleation and elongation by interacting with barbed ends (fast-growing ends) of actin filaments, but also accelerates disassembly of actin through encircling and severing filaments.

2011年12月22日 · INF2 encodes a formin protein that interacts with the Rho-GTPase CDC42 and myelin and lymphocyte protein (MAL) that are implicated in essential steps of myelination and myelin maintenance. We...

In this review, we summarize the structure, biochemical features and functions of INF2, conduct a systematic and comprehensive analysis of the pathogenic INF2 mutations, including a detailed study exon-by-exon of patient cases and mutations, address the impact of the pathogenic mutations on the structure, regulation and known functions of INF2 ...

研究表明， 内质网 接触位点发生线粒体收缩和分裂，而通过INF2蛋白和肌凝蛋白II的招募， 内质网-线粒体交界处的 肌动蛋白 聚合是有效分裂所必需的。

INF2 Is a WASP homology 2 motif-containing formin that severs actin filaments and accelerates both polymerization and depolymerization. J Biol Chem. Sep 2006, 281 (36): 26754–67.

2024年1月17日 · Inverted formin 2 (INF2), which resides in the endoplasmic reticulum (ER), has been found to accelerate actin polymerization and drive mitochondrial fission. In this study, we...

该基因代表了甲醛蛋白家族的成员。 由于在编码蛋白的 N 末端存在一个透明抑制结构域，因此它被认为是一种透明形式。 对类似小鼠蛋白质的研究表明，由该基因座编码的蛋白质可能在肌动蛋白丝的聚合和解聚中发挥作用。 该位点的突变与局灶性节段性肾小球硬化症 5 有关。 [RefSeq 提供，2010 年 8 月] This gene represents a member of the formin family of proteins.

Inf2 instances are the first inference-optimized instances in Amazon EC2 to support scale-out distributed inference with ultra-high-speed connectivity between Inferentia chips. You can now efficiently and cost-effectively deploy models with hundreds of billions of parameters across multiple chips on Inf2 instances.

Inf2 实例是 Amazon EC2 中的首个推理优化实例，可通过 Inferentia 芯片之间的超高速连接支持横向扩展分布式推理。 您现在可以在 Inf2 实例上跨多个芯片经济高效地部署具有数千亿个参数的模型。