Inhibin, beta A, also known as INHBA, is a protein which in humans is encoded by the INHBA gene. [5] . INHBA is a subunit of both activin and inhibin, two closely related glycoproteins with opposing biological effects. The inhibin beta A subunit joins the alpha subunit to form a pituitary FSH secretion inhibitor.

2024年12月25日 · INHBA (Inhibin Subunit Beta A) is a Protein Coding gene. Diseases associated with INHBA include Ovary Adenocarcinoma and Sex Cord-Gonadal Stromal Tumor. Among its related pathways are Signaling by TGFB family members and Peptide hormone metabolism.

In this study we investigated the effects and mechanisms of tumor intrinsic INHBA on carcinogenesis, tumor immunity and PD-L1 blockade. Bioinformatic analysis on the TCGA database revealed that...

2024年2月15日 · Here, we identified INHBA (+) CAFs as key players in tumor promotion and immunosuppression. Spatiotemporal analyses of patient-matched primary, metastatic, and recurrent ovarian carcinomas...

INHBA（inhibin beta A）是一个二聚体蛋白，由抑制素A（Inhibin A）和 激活素A （Activin A）组成，此前有许多研究证明INHBA能影响干细胞的增殖与分化。 其中激活素A是重要的皮肤衰老相关分泌表型（senescence-associated secretory phenotype —— SASP ）之一，主要起到抑制血管 ...

该基因编码 TGF-β (转化生长因子-β) 蛋白质超家族的成员。 编码的前原蛋白经过蛋白水解处理，生成二聚体激活素和抑制素蛋白复合物的一个亚基。 这些复合物分别激活和抑制垂体分泌促卵泡激素。 编码的蛋白质还在眼睛、牙齿和睾丸发育中发挥作用。 该基因表达升高可能与人类患者的癌症恶病质有关。 [RefSeq 提供，2016 年 8 月] This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins.

2025年1月4日 · Title: INHBA is Enriched in HPV-negative Oropharyngeal Squamous Cell Carcinoma and Promotes Cancer Progression. FOXA2-initiated transcriptional activation of INHBA induced by methylmalonic acid promotes …

介绍了抑制素α亚基基因 (INHA)、抑制素βA亚基基因 (INHBA)、抑制素βB亚基基因 (INHBB)的克隆、结构、定位、多态性、表达、分子调节及其与殖性能和癌症的关系。 抑制素-βA是一种糖蛋白激素。

Inhibin subunit βA (INHBA) is a protein-coding gene belonging to the transforming growth factor β (TGFβ) superfamily, which is associated with the development of a variety of cancers. However, the role of INHBA in head and neck squamous cell carcinoma (HNSC) remains unclear.

Accumulating evidence indicates that INHBA (Inhibin β-A, a member of the TGF-β superfamily) functions as an oncogene in cancer progression. However, little is known as to how INHBA regulates the progression and aggressiveness of breast cancer (BC). This study explored the function and underlying mec …