2020年1月1日 · iNOS is important enzyme that utilizes oxygen to generate nitric oxide (NO) under stress conditions. Accumulating evidence indicate that iNOS-derived NO has a high impact on the metabolic response. INOS-derived NO greatly affect the whole body glucose and lipids metabolism via different mechanisms.

Study objectives: Nitric oxide (NO) exists in the human breath, but little is known about its site of origin or enzyme source. The aims of this study were to locate the main site of NO release into hu man breath and to decide whether the inducible isoform of NO synthase (iN OS) and nasal bacteria contribute to breath NO.

This review summarizes the structure, function, and regulation of iNOS, with focus on the development of iNOS inhibitors (historical and recent).

Understanding the molecular mechanisms regulating the iNOS pathway in normal and hyperglycemic conditions would help to explain some of vascular abnormalities observed in type 2 diabetes mellitus (T2DM). Previous studies have reported increased myocardial iNOS activity and expression in heart failure (HF).

2024年1月10日 · iNOS全称为inducible nitric oxide synthase，即诱导型一氧化氮合酶。 它是一种酶类蛋白质，主要被激活后在细胞内合成一氧化氮（NO）等一系列氮化合物。 致炎因子、病毒感染或放射线等外界因素都能引起iNOS的产生，但正常情况下它的表达量较低。

Lipopolysaccarides and cytokines, such as tumor necrosis factor, interleukin-1 and interferon-gamma, have been shown to induce iNOS in the endothelium, vascular smooth muscle cells, macrophages and different parenchymal cells.

2018年2月14日 · Inducible nitric oxide synthase (iNOS) is a key inflammatory mediator of sepsis. However, the therapeutic benefit of iNOS inhibition in sepsis is still controversial, and...

这篇综述着重于诱导型一氧化氮合酶（iNOS）产生一氧化氮（NO）及其在生理和病理生理条件下的调控。 NO是生物中重要的生物介质，是使用NADPH和分子氧从L-精氨酸合成的。

iNOS的转染可以完全防止由球囊损伤所致的内膜肌层53%的增厚；而应用NOS抑制剂之后，此效应可以被抵消。 这些结果表明，血管内皮损伤后iNOS和eNOS的上调,恢复血管的NO产量，可能是血管受损后的一种代偿机制。

诱导型一氧化氮合酶 (inducible nitric oxide sythase，iNOS)是细胞内重要的功能酶，参与产生一氧化氮 (nitric oxide，NO)。 NO参与神经传导、免疫和氧化应激等多种生理性调节，在一些病理条件下如炎症、癌症等情况下过量表达。