Inducible Nitric Oxide Synthase: Regulation, Structure, and …
Many potent iNOS inhibitors with high selectivity over related NOS isoforms, neuronal NOS (nNOS) and endothelial NOS (eNOS), have been discovered, and these drugs have shown …
Effects of selective inhibition of nNOS and iNOS on neuropathic pain …
Our study innovatively shows that nNOS may strongly modulate nociceptive transmission in rats with neuropathic pain, while iNOS may partially participate in the development of nociceptive …
Inducible nitric oxide synthase: Regulation, structure, and inhibition
A better understanding of iNOS' complex functions is necessary before specific drug candidates can be identified for classical indications such as sepsis, heart failure, and pain; however, …
iNOS-mediated nitric oxide production and its regulation
2004年6月25日 · This review focuses on the production of nitric oxide (NO) by inducible nitric oxide synthase (iNOS) and its regulation under physiological and pathophysiological …
Potential role of nitric oxide synthase isoforms in pathophysiology of ...
2014年8月6日 · Overproduction of NO by the neuronal isoform of nitric oxide synthase (nNOS) is one of the fundamental causes underlying neurodegenerative disorders and neuropathic pain …
Inducible nitric oxide synthase: Regulation, structure, and …
2019年6月13日 · A better understanding of iNOS’ complex functions is necessary before specific drug candidates can be identified for classical indications such as sepsis, heart failure, and …
GW274150, a novel and highly selective inhibitor of the inducible ...
2006年1月1日 · The role of nitric oxide produced by iNOS in the FCA and CCI induced hypersensitivity to pain and the FCA-induced edema is confirmed by the fact that a highly …
NO Inhibits Cytokine-Induced iNOS Expression and NF-κB …
1998年11月1日 · Excessive NO production by augmented iNOS expression in the blood vessel, such as in inflammation, atherosclerosis, and septic shock, could be terminated not only via …
GW274150, a novel and highly selective inhibitor of the inducible ...
We studied the role of the inducible isoform, iNOS, in two different rat pain models with an inflammatory component. iNOS was immunohistochemically detected locally in the paw 6 h …
Inducible Nitric Oxide Synthase and Inflammatory Diseases
2000年5月1日 · Nearly two decades ago, the production of nitrogen oxides was associated with inflammation. It was already known in 1981 that a marked increase in urinary nitrate excretion …