INPP5E Gene - GeneCards | INP5E Protein | INP5E Antibody
2024年12月25日 · INPP5E (Inositol Polyphosphate-5-Phosphatase E) is a Protein Coding gene. Diseases associated with INPP5E include Joubert Syndrome 1 and Impaired Intellectual …
INPP5E inositol polyphosphate-5-phosphatase E [ (human)]
2025年2月9日 · INPP5E localizes to centrosomes, chromosomes, and kinetochores in early mitosis and shuttles to the midzone spindle at mitotic exit. INPP5E is an essential point of …
INPP5E - Wikipedia
INPP5E is a phosphatidylinositol (3,4,5)-trisphosphate (PtdInsP3) and phosphatidylinositol 4,5-bisphosphate 5-phosphatase. Its intracellular localization is the primary cilium, a small …
Regulation of INPP5E in Ciliogenesis, Development, and Disease
Inositol polyphosphate-5-phosphatase E (INPP5E) is a 5-phosphatase critically involved in diverse physiological processes, including embryonic development, neurological function, immune …
Mutations in INPP5E, encoding inositol polyphosphate-5
2009年8月9日 · INPP5E localized to cilia in major organs affected by Joubert syndrome, and mutations promoted premature destabilization of cilia in response to stimulation. These data …
INPP5E and Coordination of Signaling Networks in Cilia
INPP5E is an inositol polyphosphate 5-phosphatase with a specific affinity for lipid substrates (Dyson et al., 2012). As a lipid signaling molecule, INPP5E regulates many cellular processes, …
INPP5E inositol polyphosphate-5-phosphatase E [Homo …
2025年1月4日 · we identify Inpp5e as an essential inhibitor of the PI3K/Akt/mTORC1 signaling axis in renal epithelial cells, and demonstrate a critical role for Inpp5e-dependent mTORC1 …
肌醇多磷酸-5-磷酸酶 E（INPP5E）基因 | MCE
该基因编码的蛋白质是肌醇 1,4,5-三磷酸 (InsP3) 5-磷酸酶。 InsP3 5-磷酸酶水解 Ins (1,4,5) P3，动员细胞内钙并作为第二信使介导细胞对各种刺激的反应。 对小鼠对应物的研究表明， …
Regulation of INPP5E in Ciliogenesis, Development, and Disease
2025年1月1日 · This review integrates recent findings on the role of INPP5E in regulating cellular function, development, and the pathogenesis of various human disorders, emphasizing the …
INPP5E inositol polyphosphate-5-phosphatase E - NIH Genetic …
2024年10月6日 · The ciliary gene INPP5E confers dorsal telencephalic identity to human cortical organoids by negatively regulating Sonic hedgehog signaling. Schembs L, Willems A, …