2024年12月25日 · INSRR (Insulin Receptor Related Receptor) is a Protein Coding gene. Diseases associated with INSRR include Rickettsialpox and Regular Astigmatism. Among its related pathways are GPCR Pathway and ERK Signaling.

Insulin receptor-related protein is a protein that in humans is encoded by the INSRR gene. [5] [6] [7]

Enables transmembrane receptor protein tyrosine kinase activity. Involved in actin Cytoskeleton reorganization; cellular response to alkaline pH; and protein autophosphorylation. Part of receptor complex. [provided by Alliance of Genome Resources, Apr 2022]

Identification of INSRR as an immune-related gene in the tumor microenvironment of glioblastoma by integrated bioinformatics analysis. Probing Structure and Function of Alkali Sensor IRR with Monoclonal Antibodies.

2022年8月17日 · Here, we examined the insrr function during the Xenopus laevis early development by the morpholino-induced knockdown. We demonstrated that insrr downregulation leads to development retardation, which can be restored by the incubation of embryos in an alkaline medium.

2023年4月26日 · The cross-analysis of DEGs and DMGs revealed that INSRR was an immune-related biomarker in the TCGA GBM cohort. According to GSEA, the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway with INSRR abnormal expression were IgA-produced intestinal immune network and Alzheimer's disease, …

2023年4月26日 · We identified an immune-related predictive biomarker, INSRR. INSRR is an insulin receptor that can be activated by basic extracellular mediators . It does not recognize either insulin or any identified insulin-related peptides. INSRR mRNA is detected in the nervous system and peripheral tissues .

2001年1月11日 · Receptor with tyrosine-protein kinase activity. Functions as a pH sensing receptor which is activated by increased extracellular pH. Activates an intracellular signaling pathway that involves IRS1 and AKT1/PKB. Showing features for binding site, active site. Gene Ontology (GO) annotations organized by slimming set. Search…

Differentially expressed genes (DEGs) and differentially mutated genes (DMGs) were identified according to the ImmuneScore, and the insulin receptor-related receptor (INSRR) was determined as an immune-related biomarker. The current study aimed to provide a new valuable target for the immunotherapy of. GBM.

2025年2月8日 · Gene ID: 60663, updated on 8-Feb-2025. Predicted to enable insulin receptor activity and insulin receptor substrate binding activity. Involved in protein autophosphorylation. Predicted to be part of insulin receptor complex. Predicted to …