After a meal, insulin suppresses lipolysis through the activation of its downstream kinase, Akt, resulting in the inhibition of protein kinase A (PKA), the main positive effector of lipolysis. …

TSC2-deficient MEFs differentiate in an insulin-independent manner and give rise to insulin resistant adipocytes. Insulin signaling through IRS-1 and IRS-2 has been shown to be an …

Insulin can activate its responses in adipose tissue through two INSR splicing variants: INSR-A, which is predominantly expressed in mesenchymal and less-differentiated cells and mainly …

2023年3月1日 · The proposed mechanism of the antidiabetic action of stevioside includes: (i) induction of β-cell regeneration and increase in insulin release possible via increased …

2021年4月6日 · Insulin suppression of lipolysis in adipocytes is a major action by which insulin regulates systemic metabolism. The precise mechanisms by which insulin suppresses lipolysis …

After a meal, insulin suppresses lipolysis through the activation of its downstream kinase, Akt, resulting in the inhibition of protein kinase A (PKA), the main positive effector of lipolysis. …

2022年6月1日 · Insulin stimulates glucose uptake into adipocytes via mTORC2/AKT signaling and GLUT4 translocation and directs glucose carbons into glycolysis, glycerol for TAG synthesis, …

2022年8月18日 · Adipocytes sequester triglyceride (TG) in fed conditions stimulated by insulin, while in fasting catecholamines trigger TG hydrolysis, releasing glycerol and fatty acids (FAs).

2009年7月10日 · This study demonstrates that activation of mTORC1 signaling is a critical step in adipocyte differentiation and identifies TSC2 as a primary target of Akt driving this process. …

2023年4月1日 · Adipocytes sequester triglyceride (TG) in fed conditions stimulated by insulin, while in fasting catecholamines trigger TG hydrolysis, releasing glycerol and fatty acids (FAs).