2020年8月11日 · This review focuses on methods used to calculate insulin clearance: from the early surrogate indices employing C-peptide:insulin molar ratio, to direct measurement methods used in animal models, to modeling-based techniques to estimate the components of insulin clearance (hepatic versus extrahepatic).

Insulin clearance is critical since it contributes to the physiologic levels of insulin, which regulates insulin action and signaling. Both insulin clearance and signaling depend on insulin binding to its receptor, and activation of insulin signaling pathways begins with autophosphorylation of the insulin receptor on its tyrosine residues.

This review focuses on methods used to calculate insulin clearance: from the early surrogate indices employing C-peptide:insulin molar ratio, to direct measurement methods used in animal models, to modeling-based techniques to estimate the components of insulin clearance (hepatic versus extrahepatic).

Direct measure of insulin clearance revealed it to be highly variable among even normal individuals, and to be affected by fat feeding and other physiologic factors. Insulin clearance is relatively lower in ethnic groups at high risk for diabetes such as African Americans and Hispanic Americans, compared to European Americans.

2023年4月12日 · Understanding insulin clearance and identifying its basic mechanisms can provide a different approach with which to lower insulin resistance and ameliorate its associated metabolic diseases, as is proposed by Bergman et al. . This Special Issue provides a platform on which to discuss the design and implementation of tools to pursue this goal.

Determination of systemic inulin clearance by the standard technique of constant intravenous infusion has long been accepted as a reliable method for measuring glomerular filtration rate (GFR) without urine collection, except in oedematous patients.

2022年2月15日 · Insulin clearance was assessed as insulin secretion to insulin concentration ratio. In the first study, we found OGTT/IIGI insulin clearance ratio weakly inversely related to OGTT/IIGI total GIP and intact GLP-1 (R 2 = 0.13, p < 0.02). However, insulin clearance showed some differences between sitagliptin and metformin treatment (p < 0.02).

How to measure insulin clearance Diabetes Metab Rev. 1994 Jul;10(2):119-50. doi: 10.1002/dmr.5610100205. Authors M J Castillo 1 , A J Scheen, M R Letiexhe, P J Lefèbvre. Affiliation 1 Department of Medicine, CHU Liège, University …

2018年10月11日 · On the basis of recent experimental evidence, we summarize existing evidence to suggest hepatic insulin clearance as a major and immediate regulator of systemic insulin concentrations responding within days to altered dietary …

An insulin tolerance test (ITT) is a medical diagnostic procedure during which insulin is injected into a patient's vein, after which blood glucose is measured at regular intervals. This procedure is performed to assess pituitary function, adrenal function, insulin sensitivity, [1] [2] and sometimes for other purposes.