Insulin receptor - Wikipedia
The insulin receptor is a type of tyrosine kinase receptor, in which the binding of an agonistic ligand triggers autophosphorylation of the tyrosine residues, with each subunit phosphorylating its partner.
The Insulin Receptor and Its Signal Transduction Network
2016年4月27日 · Insulin binds to two distinct sites on each a subunit of the receptor, crosslinking the two receptor halves to create high affinity. The structure of the site 1 interface has also been solved, as well as the structure of the inactive and activated tyrosine kinase, revealing the activation by phosphorylation of an autoinhibitory loop.
Activation mechanism of the insulin receptor: a structural …
The insulin receptor (IR) is a type II receptor tyrosine kinase (RTK) that plays essential roles in metabolism, growth, and proliferation. Dysregulation of IR signaling is linked to many human diseases, such as diabetes and cancers.
Insulin and IGF-I Receptor Structure and Binding Mechanism
The insulin and IGF-I receptors are members of the superfamily of receptor tyrosine kinases (RTKs). Unlike most RTKs that are single-chain monomeric transmembrane polypeptides, the insulin and IGF-I receptors are covalent dimers composed of two extracellular α subunits and two transmembrane β subunits containing the tyrosine kinase domains.
Structure and Mechanism of the Insulin Receptor Tyrosine Kinase
2010年1月1日 · This chapter sheds light on the structure and mechanism of the insulin receptor tyrosine kinase (RTK). The actions of insulin hormone are mediated by the insulin receptor, a member of the RTK family of cell surface receptors.
The insulin receptor: structure, function, and signaling
The insulin receptor is a member of the ligand-activated receptor and tyrosine kinase family of transmembrane signaling proteins that collectively are fundamentally important regulators of cell differentiation, growth, and metabolism. The insulin receptor has a …
Receptor Tyrosine Kinases and the Insulin Signaling System
2018年1月26日 · Protein tyrosine kinases (PTKs) are encoded by a large multigene family. PTKs regulate many aspects of metabolism, growth, and cancer progression – including cell proliferation, differentiation, and survival, adhesion and motility, and systemic nutrient homeostasis (Schlessinger 2014; Robinson et al. 2000; Lemmon and Schlessinger 2010).
The Insulin Receptor Tyrosine Kinase | SpringerLink
The insulin receptor is a tyrosine protein kinase. This enzymatic activity of the insulin receptor was first recognized in 1982, and is an initial, critical component of the mechanism by which insulin controls cell metabolism. Insulin binds to the extracellular...
Second, the insulin receptor is a receptor/tyrosine kinase, an enzyme family whose members play critical regulatory roles in development, cell division, and me-
Insulin Receptor Kinase - an overview | ScienceDirect Topics
The insulin receptor is a protein tyrosine kinase that upon binding insulin, results in the phosphorylation of intracellular substrates. Upon phosphorylation, these substrates interact and activate other molecules that modulate intracellular metabolism.