Integrin subunits span the cell membrane and have short cytoplasmic domains of 40–70 amino acids. The exception is the beta-4 subunit, which has a cytoplasmic domain of 1,088 amino acids, one of the largest of any membrane protein.

Integrin-engagement triggers the formation of membrane extensions that are required for cell spreading on ECM surfaces, for migration of cells into sheets of other cells, or for engulfment of particles or pathogens by phagocytic cells.

2023年1月2日 · Integrin functions are dependable on a delicate balance between active and inactive status via multiple mechanisms, including protein-protein interactions, conformational changes, and...

Integrins are large, membrane-spanning, heterodimeric proteins that are essential for a metazoan existence. All members of the integrin family adopt a shape that resembles a large “head” on two “legs,” with the head containing the sites for ligand ...

An integrin molecule is composed of two noncovalently associated transmembrane glycoprotein subunits called α and β (Figure 19-64; see also Figure 19-12B).

2007年8月5日 · The integrin tails recruit several proteins, such as talin, that bind actin filaments, and thus form a connection to the cytoskeleton, a connection that is essential for most, if not all, integrin-mediated functions.

2019年6月10日 · Here, we review this work first by providing an overview of how integrin function is regulated from both a biochemical and a mechanical perspective, affecting integrin cell-surface availability...

Mutations in integrins or the major effectors of integrin signalling pathways cause defective organ development, immunodeficiency, cancer or autoimmune disease. Understanding of the signalling events that drive integrin activation and signalling is therefore crucial to uncover the molecular mechanisms of these diseases.

2021年5月24日 · Integrin-mediated cell adhesion is regulated at multiple levels. These include the regulation of integrin expression, ligand availability, heterodimer specificity and activity, and the recruitment of different intracellular proteins.

2002年9月20日 · In this review, I will first give a brief overview of the integrin family to set the context and then review the recent structural data and experiments arising from them, which give insight into some long-standing questions concerning integrin functions.