1999年6月1日 · Patients with inv (16) usually correspond to the subclass of AML M4, with a specific abnormal eosinophil component and is considered as a distinct entity in correlation with these specific chromosomal abnormalities. These cases of AML M4 are referred as AML M4EO.

2021年5月13日 · The fusion oncogene CBFβ-SMMHC expressed in AML with the chromosome inversion inv (16) (p13q22) acts as a driver oncogene in hematopoietic stem cells and induces AML.

最常见的染色体重组，就是16号染色体上发生倒位，在医学上被记为 inv (16)。 染色体倒位指的是一条染色体裂成两段，这两条含DNA的染色体片段位置颠倒，重新粘合成一条染色体。 相对少见的是，16号染色体的两份拷贝发生易位现象，这在医学上被记为 t (16;16)。 以上两类遗传物质重组会使得16号染色体上的两个基因， CBFB 和 MYH11，发生融合。 这些遗传物质发生突变现象可能是5%到8%的成人患上急性髓系白血病的诱因。 正常人在一生中，体内的基因都可能发生这些突 …

Inv (16) (p13q22) is associated with acute myeloid leukemia subtype M4Eo, which is characterized by the presence of myelomonocytic blasts and atypical eosinophils. This chromosomal rearrangement results in the fusion of CBFB and MYH11 genes. Mouse models indicate that the fusion gene, Cbfb-MYH11, inhibits differentiation of hematopoietic cells.

2003年7月15日 · Acute myeloid leukemias (AMLs) carrying inv (16)/t (16;16) chromosomal abnormalities are associated with a good prognosis. However, studies of this AML subtype have been hampered by the few number of patients reported, frequently collectively considered with those with AML carrying the t (8;21) translocation.

inv (16)，是一种 急性髓细胞白血病 （AML）相关的染色体异常，预后良好。 BCR-ABL和inv (16)的共同发生极为罕见。 2018年，美国的Ruiz S等人报道了一例罕见的t (9;22)和 inv (16)并存病例。 一、患者简介. 年轻成年女性，无既往病史，患者主要表现为白细胞显著增多。 二、形态学检测. 1、血液涂片. 在 中性粒细胞 增多的背景下原始细胞占50%（图A，单箭头指示，WG染色×1000）， 嗜酸性粒细胞增多 （图A，双箭头指示）以及嗜碱性细胞增多（图B，箭头指示）。 …

2018年4月23日 · 急性髓系白血病伴inv（16）（p13.1q22）或t（16；16）（p13.1;q22）具有较长的完全缓解期。 KIT突变复发率高，预后差，FLT3突变预后也不好， +22预后较好。

Inv (16) (p13q22) and t (16;16) (p13;q22), that we refer as inv (16) and t (16;16) respectively from now, are recurring chromosomal rearrangements commonly associated with the M4Eo subtype of AML but also reported in the AML M2, M5 subtypes, and in patients with morphological features of higher risk MDS [1, 2].

2013年1月10日 · We analyzed CBFB-MYH11 fusion types in 208 inv (16)/t (16;16) patients with de novo disease, and compared clinical and cytogenetic features and the KIT mutation status between type A (n = 182; 87%) and non–type A (n = 26; 13%) patients.

2020年1月30日 · Abnormalities of chromosome 16 are found in about 5–8% of acute myeloid leukemia (AML). The AML with inv (16) (p13.1q22) or t (16;16) (p13.1;q22) is associated with a high rate of complete remission (CR) and favorable overall survival (OS) when treated with high-dose Cytarabine.