Ionophores are chemical compounds that reversibly bind and transport ions through biological membranes in the absence of a protein pore. This can disrupt the membrane potential, and thus these substances could exhibit cytotoxic properties. [1] .

An ionophore is a small, lipid-soluble molecule that acts as an ion carrier, facilitating the transport of ions across membranes down their electrochemical gradient. They can be classified as channel formers or mobile carriers based on their mechanism of action. You might find these chapters and articles relevant to this topic.

Un ionóforo es una molécula soluble en lípidos, usualmente sintetizada por microorganismos para transportar iones a través de una bicapa lipídica de membrana celular. Existen dos clasificaciones para los ionóforos.

Recent research is focusing on the importance of dietary zinc combined with zinc ionophores which may improve cellular absorption and increase immune function. Zinc is an essential mineral well-known as the single most important micronutrient for proper function of …

Calcium ionophores are generally assumed to directly facilitate the transport of Ca2+ across the plasma membrane. The ability of Ca2+ ionophores ionomycin and A23187 to increase Ca2+ concentration in the cytosol ( [Ca2+]i) in different cells was analyzed in …

Jul 15, 2021 · Calcium ionophore (A23187) is a highly selective calcium ionophore, which can form stable complex with Ca 2+ and pass through the cell membrane at will, effectively increasing intracellular Ca 2+ levels. It has been reported that calcium ionophore (A23187) can activate oocytes and obtain normal embryos.

Jan 15, 2023 · For many years, ionophores have been used to control coccidiosis in poultry. However, misuse of ionophores can cause toxicity with significant clinical symptoms. The most critical factors influencing ionophores' toxicity are administration dose, species, and animal age.

Calcium Ionophore A23187 is a potent inducer of phosphorylation of Toxoplasma eukaryotic initiation factor-2α (eIF2α). It also induces apoptosis in mouse lymphoma cell line (S49)7 but also has been shown to block apoptosis in other systems, such as when interleukin-3 (IL-3) is withdrawn from IL-3-dependent cells.

Jul 28, 2024 · Explore the mechanisms, types, and immune benefits of zinc ionophores, including quercetin, EGCG, and pyrithione. Zinc ionophores are gaining attention for their potential to enhance the immune system by facilitating zinc transport across cell membranes.

En química, un ionóforo (del griego ion y -phore 'portador de iones') es una especie química que une reversiblemente los iones. Muchos ionóforos son entidades liposolubles que transportan iones a través de la membrana celular.