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2021年9月10日 · We investigated iPLA 2-VIA in Drosophila melanogaster by determining its endogenous expression pattern and generating a new null mutant. iPLA 2-VIA is expressed ubiquitously at low levels in imaginal tissues. Null mutants are viable and show no synthetic lethality or sterility with two key phosphatidylcholine (PC) metabolizing enzymes.

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2021年2月4日 · Here, we demonstrate that by hydrolyzing 15-HpETE-PE, iPLA 2 β averts ferroptosis, whereas its genetic or pharmacological inactivation sensitizes cells to ferroptosis.

2024年3月15日 · iPLA2β 是由 PLA2G6 基因编码的一种重要的酶，属于依赖钙的磷脂酶A2家族，参与脂质代谢和膜重塑。 该蛋白在包括大脑、肝脏、脾脏、肌肉和睾丸在内的多种组织中都有表达。

2018年2月22日 · Here, we present a crystal structure of iPLA 2 β that significantly revises existing mechanistic models. The catalytic domains form a tight dimer. They are surrounded by ankyrin repeat domains...

由于 Ca 2+ 非依赖性磷脂酶 A 2 β（iPLA 2 β、 PLA2G6 或 PNPLA9 基因）可以优先水解过氧化磷脂，它可以消除铁死亡的 15-HpETE-PE 死亡信号。 在这里，我们证明通过水解 15-HpETE-PE，iPLA 2 β 可避免铁死亡，而其遗传或药理学失活使细胞对铁死亡敏感。 鉴于 PLA2G6 突变与神经退行性变有关，我们检查了患有帕金森病 (PD) 相关突变 (fPD R747W ) 患者的成纤维细胞，发现选择性降低 15-HpETE-PE 水解活性、15-HpETE-PE 积累和对铁死亡的敏感性升高。 …

Calcium-independent phospholipase A 2 γ (iPLA 2 γ)/patatin-like phospholipase domain-containing lipase 8 (PNPLA8) is one of the iPLA 2 enzymes, which do not require Ca 2+ ion for their activity. iPLA 2 γ is a membrane-bound enzyme with unique features, including the utilization of four distinct translation initiation sites and the presence ...

2021年6月15日 · Here, we identify iPLA2β as a critical regulator for p53-driven ferroptosis upon reactive oxygen species (ROS)-induced stress. The calcium-independent phospholipase iPLA2β is known to cleave acyl tails from the glycerol backbone of lipids and release oxidized fatty acids from phospholipids.