ERN1 - Wikipedia
The serine/threonine-protein kinase/endoribonuclease inositol-requiring enzyme 1 α (IRE1α) is an enzyme that in humans is encoded by the ERN1 gene. [5][6] The protein encoded by this gene …
IRE1α is an endogenous substrate of endoplasmic-reticulum ... - PubMed
Here we discover that IRE1α, the sensor of the unfolded protein response (UPR), is a bona fide substrate of the Sel1L-Hrd1 ERAD complex. ERAD-mediated IRE1α degradation occurs under …
Mammalian IRE1α dynamically and functionally coalesces with …
2024年5月7日 · Here we report that, in mammalian cells, formation of IRE1α clusters is an ER membrane-bound phase separation event that is coupled to the assembly of stress granules …
探索IRE1蛋白：揭开它在细胞信号传导中的神秘面纱 - 知乎
IRE1 （Immunoglobulin-Regulated Enhancer 1）是一种 转录因子，主要参与免疫细胞的生长和活化。 IRE1在多种免疫细胞中表达，包括T细胞、B细胞、巨噬细胞和树突状细胞等。 它通过结 …
Frontiers | IRE1α Implications in Endoplasmic Reticulum Stress …
Inositol-requiring transmembrane kinase/endoribonuclease 1α (IRE1α) is the most prominent and evolutionarily conserved endoplasmic reticulum (ER) membrane protein. This transduces the …
IRE1α governs cytoskeleton remodelling and cell migration
2018年7月16日 · IRE1α is a serine/threonine protein kinase and endoribonuclease that catalyses the unconventional processing of the messenger RNA encoding X-box binding protein 1...
The Structure, Activation and Signaling of IRE1 and Its Role in ...
Inositol-requiring enzyme type 1 (IRE1) is a serine/threonine kinase acting as one of three branches of the Unfolded Protein Response (UPR) signaling pathway, which is activated upon …
Regulated IRE1α-dependent decay (RIDD)-mediated …
2022年5月6日 · IRE1α is constitutively active in several cancers and can contribute to cancer progression. Activated IRE1α cleaves XBP1 mRNA, a key step in production of the …
刘勇课题组揭示未折叠蛋白响应分子IRE1α与应激颗粒共聚集的动 …
2024年5月8日 · 为了深入解析在哺乳动物细胞中IRE1α聚集簇的结构与功能特性，研究人员利用免疫荧光检测、活细胞成像、光遗传学、免疫共沉淀及细胞组分分离等分子与细胞生物学技术手 …
The unfolded protein response sensor IRE1alpha is required at …
Two major proximal sensors of the UPR are inositol-requiring enzyme 1alpha (IRE1alpha), an ER transmembrane protein kinase/endoribonuclease, and ER-resident eukaryotic translation …