The serine/threonine-protein kinase/endoribonuclease inositol-requiring enzyme 1 α (IRE1α) is an enzyme that in humans is encoded by the ERN1 gene. [5][6] The protein encoded by this gene is the ER to nucleus signalling 1 protein, a human homologue of the yeast Ire1 gene product.

Here we discover that IRE1α, the sensor of the unfolded protein response (UPR), is a bona fide substrate of the Sel1L-Hrd1 ERAD complex. ERAD-mediated IRE1α degradation occurs under basal conditions in a BiP-dependent manner, requires both the intramembrane hydrophilic residues of IRE1α and the lectin protein OS9, and is attenuated by ER stress.

2024年5月7日 · Here we report that, in mammalian cells, formation of IRE1α clusters is an ER membrane-bound phase separation event that is coupled to the assembly of stress granules (SGs). In response to...

IRE1 （Immunoglobulin-Regulated Enhancer 1）是一种 转录因子，主要参与免疫细胞的生长和活化。 IRE1在多种免疫细胞中表达，包括T细胞、B细胞、巨噬细胞和树突状细胞等。 它通过结合特异性抗原，激活一系列信号转导通路，从而诱导细胞增殖、分化和功能的发挥。 IRE1的二级结构主要由两个主要的功能区域组成： IR region 和 EGF-like域。 IR region是一个核心的α螺旋结构，螺旋轴心位于IRE1的短轴区域。 这一区域的功能域包括一个N-末端α螺旋、一个中央β页和 …

Inositol-requiring transmembrane kinase/endoribonuclease 1α (IRE1α) is the most prominent and evolutionarily conserved endoplasmic reticulum (ER) membrane protein. This transduces the signal of misfolded protein accumulation in the ER, named as ER stress, to the nucleus as “unfolded protein response (UPR).”

2018年7月16日 · IRE1α is a serine/threonine protein kinase and endoribonuclease that catalyses the unconventional processing of the messenger RNA encoding X-box binding protein 1...

Inositol-requiring enzyme type 1 (IRE1) is a serine/threonine kinase acting as one of three branches of the Unfolded Protein Response (UPR) signaling pathway, which is activated upon endoplasmic reticulum (ER) stress conditions.

2022年5月6日 · IRE1α is constitutively active in several cancers and can contribute to cancer progression. Activated IRE1α cleaves XBP1 mRNA, a key step in production of the transcription factor XBP1s. In...

2024年5月8日 · 为了深入解析在哺乳动物细胞中IRE1α聚集簇的结构与功能特性，研究人员利用免疫荧光检测、活细胞成像、光遗传学、免疫共沉淀及细胞组分分离等分子与细胞生物学技术手段，发现在不同应激条件刺激下，IRE1α聚集体的形成是在内质网膜附近发生的相分离事件，位于内质网的IRE1α聚集簇可以动态地与应激颗粒结合，并与应激颗粒的组装同步偶联，形成IRE1α-SG共聚集簇；IRE1α胞质段连接内质网跨膜结构域...

Two major proximal sensors of the UPR are inositol-requiring enzyme 1alpha (IRE1alpha), an ER transmembrane protein kinase/endoribonuclease, and ER-resident eukaryotic translation initiation factor 2alpha (eIF2alpha) kinase (PERK).