Stock solutions of 5-ISMN (analyte) and its internal standard (13 C 6-5-ISMN) at the concentration of 0.5 mg/mL were prepared by acetonitrile-water (50 : 50, v/v). Stock solutions of 5-ISMN in …

A new controlled-release isosorbide-5-mononitrate (CR-ISMN) preparation has been developed to meet the requirement for a low nitrate concentration interval in order to avoid nitrate tolerance. …

As the vast majority of oral prophylactic nitrates prescribed are preparations of ISMN, this paper will consider these only. There is only one modified release preparation of ISDN (Isoket …

2010年11月15日 · In this study, 5-ISMN sustained-release capsule was prepared successfully and the preparation had several novelties and advantages: (1) the long-term stability of the …

2020年6月2日 · 5-ISMN is a charged, hydrophilic and low ultraviolet-absorbing (UV) molecule which is challenging to determine specifically and sensitively in biological matrices. To better …

After oral administration of ISMN as a solution or immediate-release tablets, maximum plasma concentrations of ISMN are achieved in 30 to 60 minutes, with an absolute bioavailability of …

2010年4月2日 · A sensitive, selective, and simple liquid chromatography-tandem mass spectrometry method has been developed for the simultaneous separation and determination …

Isosorbide mononitrate (ISMN) is widely used for the prophylaxis of angina pectoris. As the active metabolite of isosorbide dinitrate, ISMN does not require first-pass metabolism for activation …

A new controlled-release isosorbide-5-mononitrate (CR-ISMN) preparation has been developed to meet the requirement for a low nitrate concentration interval in order to avoid nitrate tolerance.

Twenty-four patients with severe stable angina pectoris were included in a randomized, double-blind, placebo-controlled, cross-over study to assess the efficacy of a controlled-release …