The isthmic organizer, or isthmus organizer, also known as the midbrain−hindbrain boundary (MHB), is a secondary organizer region that develops at the junction of the midbrain and metencephalon (embryonic hindbrain). [1] The MHB expresses signaling molecules that regulate the differentiation and patterning of the adjacent neuroepithelium.This allows for the development of the midbrain and ...

2001年2月1日 · The ectopic expression of Gbx2 in the mesencephalon results in a transient shift of the isthmic organizer rostrally, showing that Gbx2 is involved in organizer positioning by repressing Otx2 and ...

Two organizing centres operate at long-range distances within the anterior neural plate to pattern the forebrain, midbrain and hindbrain. Important progress has been made in understanding the formation and function of one of these organizing centres, the isthmic organizer, which controls the development of the midbrain and anterior hindbrain.

The isthmic organizer is a signaling center that secretes fibroblast growth factor 8 (FGF8), a key molecule required for orchestrating multiple stages of cerebellar development (Crossley et al., 1996; Martinez et al., 1999), with an early role in maintaining the posterior border of Otx2 expression (Foucher et al., 2006).

The isthmic organizer, which is located at the midbrain–hindbrain boundary, plays an essential role in development of the midbrain and anterior hindbrain. It has been shown that homeobox genes regulate establishment of the isthmic organizer, but the ...

1999年9月9日 · The homeobox gene Otx2 is expressed in the anterior neural tube with a sharp limit at the midbrain/hindbrain junction (the isthmic organizer)1. Otx2 inactivation experiments have shown that this ...

2000年6月1日 · The isthmic organizer possesses midbrain- and cerebellum-inducing properties, and its positioning at the midbrain–hindbrain boundary is a crucial event that controls midbrain and cerebellum development. Recent work has shown that two transcription factors, Otx2 and Gbx2, are instrumental in positioning the isthmic organizer at the midbrain ...

在早期神经管发育中，在中脑和后脑交界处存在一个称为菱脑峡的区域，它分泌FGF8和WNT1等诱导分子，并作为一个组织中心（Isthmic Organizer）来调控中脑和后脑的发育。

The isthmic organizer possesses midbrain- and cerebellum-inducing properties, and its positioning at the midbrain–hindbrain boundary is a crucial event that controls midbrain and cerebellum development. Recent work has shown that two transcription factors, Otx2and Gbx2, are instrumental in positioning the isthmic ...

2016年3月3日 · The isthmic organizer (IsO) is a signaling center that specifies the correct and distinct embryonic development of the dopaminergic midbrain and serotonergic hindbrain. The IsO is a linear boundary between the two brain regions, emerging at around embryonic day 7-8 of murine embryonic development, that shapes its surroundings through the ...