2024年12月25日 · ISYNA1 (Inositol-3-Phosphate Synthase 1) is a Protein Coding gene. Diseases associated with ISYNA1 include Congenital Myopathy 4A, Autosomal Dominant. Among its related pathways are Inositol phosphate metabolism and Metabolism. Gene Ontology (GO) annotations related to this gene include inositol-3-phosphate synthase activity.

We demonstrate that SLC5A3 is essential to support a myo-inositol auxotrophy in AML. The commonality among SLC5A3-dependent AML lines is the transcriptional silencing of ISYNA1, which encodes the rate-limiting enzyme for myo-inositol biosynthesis, inositol-3 …

该基因编码肌醇-3-磷酸合成酶。 编码的蛋白质通过催化葡萄糖 6-磷酸向肌醇 1-磷酸的限速转化，在肌醇生物合成途径中发挥关键作用。 已观察到该基因编码多种亚型的选择性剪接转录变体，该基因的假基因位于 4 号染色体的短臂上。 [RefSeq 提供，2011 年 11 月] This gene encodes an inositol-3-phosphate synthase Enzyme.

2025年2月9日 · The myo-inositol biosynthesis rate-limiting enzyme ISYNA1 suppresses the stemness of ovarian cancer via Notch1 pathway. Musashi2 promotes the progression of pancreatic cancer through a novel ISYNA1-p21/ZEB-1 pathway. The ISYNA1 was an important regulatory factors and related networks were involved in multiple functional processes.

Assigned HPA protein class (es) for the encoded protein (s). Number of protein-coding transcripts from the gene as defined by Ensembl. A summary of the overall protein expression profile across the analyzed normal tissues based on knowledge-based annotation, presented in the Tissue resource. "Estimation of protein expression could not be performed.

Title: The myo-inositol biosynthesis rate-limiting enzyme ISYNA1 suppresses the stemness of ovarian cancer via Notch1 pathway. Musashi2 promotes the progression of pancreatic cancer through a novel ISYNA1-p21/ZEB-1 pathway.

2023年7月1日 · Here, we report ISYNA1, the rate-limiting enzyme in myo-inositol biosynthesis, as a suppressor of OC regulating cancer stemness. We identified ISYNA1 as a differentially expressed gene in normal ovary and ovarian cancer tissues, as well as OC cells and OCSCs. Low ISYNA1 expression correlated with poor prognosis in OC patients.

isyna1 缺陷促进 oc 细胞在体外和体内的生长、迁移和侵袭能力。isyna1 的敲低增加了 oc 细胞的干性，包括自我更新、csc 标志物表达、aldh 活性、+ /cd117 + csc。相反，异位过表达 isyna1 会抑制 oc 细胞的细胞增殖、迁移、侵袭和干性。

Here, we report ISYNA1, the rate-limiting enzyme in myo-inositol biosynthesis, as a suppressor of OC regulating cancer stemness. We identified ISYNA1 as a differentially expressed gene in normal ovary and ovarian cancer tissues, as well as OC cells and OCSCs. Low ISYNA1 expression correlated with poor prognosis in OC patients.

2024年5月5日 · Clinical resource with information about ISYNA1, An atlas of genetic influences on human blood metabolites., Large-scale genotyping identifies 41 new loci associated with breast cancer risk., and available tests.