An immunoreceptor tyrosine-based activation motif (ITAM) is a conserved sequence of four amino acids that is repeated twice in the cytoplasmic tails of non-catalytic tyrosine-phosphorylated …

生物学中，ITAM是免疫受体酪氨酸激活基序（Immunoreceptor tyrosine-based activation motif）的英文缩写，基本组成是：YXXL/V，活化受体与相应配体结合后，在细胞膜相连的一 …

Immunoreceptor tyrosine-based activation motif (ITAM) 是一种存在于细胞 膜受体的结构域。 ITAM是一种由 6-8个氨基酸残基 组成的 保守肽段，其序列为Yxx (L/I)x (6-8)Yxx (L/I)，其中 x …

The immunoreceptor tyrosine-based activation motif (ITAM) is a highly conserved region in the cytoplasmic domain of signaling chains of adapter proteins and receptors and is a critical …

2020年5月20日 · Almost all CAR constructs contain the intracellular CD3ζ domain, which contains three ITAM motifs ; these are typically the only ITAMs present in CAR constructs. Thus, …

Phosphorylated immunoreceptor signalling motifs (ITAMs) exhibit unique abilities to bind and activate Lyn and Syk tyrosine kinases [ (PUBMED:7594458) ]. Motif may be dually …

In order for the short cytoplasmic domains of the TCRαβ or γδ heterodimers to transduce extracellular stimuli into intracellular signaling, it must utilize the immunoreceptor tyrosine …

2008年5月11日 · The cytoplasmic segment of the CD3γ, CD3δ and CD3ε subunits contain a single ITAM, whereas that of the CD3ζ subunit contains three ITAM copies. According to that …

Phosphorylated ITAMs serve as docking sites for tandem SH2 domains of Syk family kinases, whereas phosphorylated ITIMs recruit tyrosine phosphatases. Signaling through ITAM-bearing …

An immunoreceptor tyrosine-based inhibitory motif (ITIM), is a conserved sequence of amino acids that is found intracellularly in the cytoplasmic domains of many inhibitory receptors of the …