Immunoreceptor tyrosine-based activation motif - Wikipedia
An immunoreceptor tyrosine-based activation motif (ITAM) is a conserved sequence of four amino acids that is repeated twice in the cytoplasmic tails of non-catalytic tyrosine-phosphorylated …
ITAM - 百度百科
生物学中，ITAM是免疫受体酪氨酸激活基序（Immunoreceptor tyrosine-based activation motif）的英文缩写，基本组成是：YXXL/V，活化受体与相应配体结合后，在细胞膜相连的一 …
Immunoreceptor Tyrosine Based Activation Motif - an …
The immunoreceptor tyrosine-based activation motif (ITAM) is a highly conserved region in the cytoplasmic domain of signaling chains of adapter proteins and receptors and is a critical …
免疫受体酪氨酸活化基序 - 维基百科，自由的百科全书
免疫受体酪氨酸活化基序（英語： immunoreceptor tyrosine-based activation motif ，缩写ITAM）是一个由十多个氨基酸构成的保守序列，常出现在免疫系统某些细胞的跨膜蛋白的胞 …
basic-9-ITAM - 知乎 - 知乎专栏
Immunoreceptor tyrosine-based activation motif (ITAM) 是一种存在于细胞 膜受体的结构域。 ITAM是一种由 6-8个氨基酸残基 组成的 保守肽段，其序列为Yxx (L/I)x (6-8)Yxx (L/I)，其中 x …
专家点评Cell | CAR T细胞疗法新思路 - 知乎 - 知乎专栏
ITAM (immunoreceptor tyrosine-based activation motif)是一个激活T细胞的重要元件，在所有CD3亚基上都有分布。 抗原结合TCR以后，激酶Lck磷酸化ITAM上的两个酪氨酸 （双磷酸 …
How ITAMs Inhibit Signaling | Science Signaling - AAAS
2011年4月19日 · Immunoreceptor tyrosine-based activation motifs (ITAMs) are used by multiple receptors to activate immune cells. However, ITAM-associated receptors can have …
Immunoreceptor tyrosine-based activation motif (ITAM), a ... - PubMed
Signal transduction by the T cell and B cell antigen receptors and by receptors for a variety of immunoglobulins' Fc region is strictly dependent on a receptor subunit cytoplasmic module …
ITAM-mediated Signaling by the T-Cell Antigen Receptor - PMC
Phosphorylation of conserved ITAM motifs in T-cell receptor tails allows them to bind the downstream kinase ZAP-70. The presence of multiple ITAMs produces the signal amplification …
The many faces of ITAMs: Trends in Immunology - Cell Press
In the immune system and beyond, signals transduced through cytoplasmic immunoreceptor tyrosine-based activation motifs (ITAMs) control a variety of key cellular responses, including …