2025年1月20日 · Itch is a unique sensation that is mediated by specialized neurons that innervate the skin. In this primer, we will discuss recent advancements that define the molecules and cells that mediate acute itch and that promote chronic itch associated with inflammatory diseases.

2021年1月14日 · Instead, a previously unrecognized basophil-leukotriene (LT) axis emerges as critical for acute itch flares. By probing fundamental itch mechanisms, our study highlights a …

In this review, we will look at the cell biology of itch, with an emphasis on the receptors, cell types, and pruriceptors that are involved in the processing of itch, focusing on the periphery and how itch is coded in the spinal cord.

Itch is a unique sensory experience that is encoded by genetically distinguishable neurons both in the peripheral nervous system (PNS) and central nervous system (CNS) to elicit a characteristic behavioral response (scratching).

2021年1月21日 · Itch is an evolutionarily conserved sensation that facilitates expulsion of pathogens and noxious stimuli from the skin. However, in organ failure, cancer, and chronic inflammatory disorders such as atopic dermatitis (AD), …

In this review we focus on the molecules, cells and circuits in the peripheral and central nervous systems that drive acute and chronic itch transmission. Understanding the itch circuitry is critical to developing new therapies for this intractable disease. Itch is defined as an unpleasant sensation that evokes a desire to scratch.

2024年10月18日 · When itchy skin becomes severe or lasts for more than six weeks, it has deleterious effects on both quality of life and productivity. Despite decades of research, the complete molecular and...

2024年9月24日 · Using cell type-specific manipulations, the opposing functions of ACC glutamatergic and GABAergic neurons in regulating acute itching are demonstrated. Photometry studies indicated that ACC glutamatergic neurons are activated during scratching induced by both histamine and chloroquine, whereas the activation pattern of GABAergic neurons is ...

为同时模拟特应性皮炎的慢性瘙痒和与过敏原有关的Acute Itch Flare，在经典特应性皮炎小鼠模型基础上，Kim实验室创制了一种新的动物模型。 首先利用 MC903 （一种卡波三醇类似物）涂抹鼠耳，诱发小鼠特应性皮炎样皮疹并模拟慢性瘙痒。 这里顺便提一句，Kim实验室也是世界上首次发现IL-4、IL-13可作用于感觉神经元上受体IL-4Rα并介导慢性瘙痒的团队哦 （Oetjen et al. Cell. 2017）。 接着，在MC903的基础上，利用 卵清蛋白 （Ovalbumin, OVA）经皮致敏的方法诱 …

Here we review what is known about the cells, molecules, and circuits involved in itch and highlight key questions that remain to be answered. Keywords: Itch, pain, DRG neurons, skin, spinal cord, Mrgpr, GRPR, histamine, and TRP