2024年12月25日 · ITGA11 (Integrin Subunit Alpha 11) is a Protein Coding gene. Diseases associated with ITGA11 include Brain Oligodendroglioma and Bile Duct Sarcoma. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and Integrin Pathway.

2024年4月8日 · Utilizing single-cell RNA sequencing and spatial transcriptomic, we identify a previously unknown PDGFRα + ITGA11 + CAF subset in early-stage bladder cancer (BCa). Multicenter clinical analysis of a 910-case cohort confirms that PDGFRα + ITGA11 + CAFs are associated with lymphovascular invasion (LVI) and poor prognosis in early-stage BCa.

Integrin alpha-11 is a protein that, in humans, is encoded by the ITGA11 gene. [5][6] This gene encodes an alpha integrin. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain.

This review provides a comprehensive exploration of Integrin α11 (ITGA11), a crucial cell adhesion receptor involved in diverse biological processes. Composed of α and β chains, ITGA11 forms heterodimers, with specific subtypes acting as primary receptors for native collagens.

2017年11月17日 · In the present study, we explored the significance of integrin alpha 11 (ITGA11), the integrin alpha subunit that selectively binds to type I collagen during tissue...

In the present study, we explored the significance of integrin alpha 11 (ITGA11), the integrin alpha subunit that selectively binds to type I collagen during tissue fibrosis in the liver, lungs and kidneys.

胃癌（GC）是全球最常见的消化系统恶性肿瘤之一，而整合素亚基α11（ITGA11）在GC中的作用和具体机制仍不清楚。 本研究探讨ITGA11在GC中的表达特征和功能。 首先，通过定量逆转录聚合酶链反应（qRT-PCR）和蛋白质印迹（WB）评估GC组织和癌旁非肿瘤组织中的ITGA11谱，并评估ITGA11与GC患者临床病理指标之间的关联。 在GC细胞系MKN45和AGS中建立ITGA11敲低模型。 通过细胞计数试剂盒-8 (CCK-8) 测定和集落形成测定来测定细胞增殖。 WB 用于测量 …

Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein contains an I domain, is expressed in muscle tissue, dimerizes with beta 1 Integrin in vitro, and appears to bind collagen in this form. Therefore, the protein may be involved in attaching muscle tissue to the extracellular matrix.

2024年2月5日 · ITGA11 demonstrated robust diagnostic and prognostic value in gastric cancer (GC) and was an independent risk factor for adverse outcomes. The patients with STAD with elevated ITGA11 expression levels had heightened immune cell infiltration and increased immune checkpoint marker expression.

2024年12月1日 · Itga11 was significantly downregulated in rBMSCs under hypoxic conditions. Overexpression of Itga11 in rBMSCs inhibited their proliferation and angiogenesis and enhanced osteogenic differentiation, while its knockdown had the opposite effect. Itga11 was found to activate the Pi3k /Akt signaling pathway in rBMSCs.