2024年12月25日 · ITGB7 (Integrin Subunit Beta 7) is a Protein Coding gene. Diseases associated with ITGB7 include Inflammatory Bowel Disease 18 and T-Cell Non-Hodgkin Lymphoma. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and Integrin Pathway.

Integrin beta-7 is an integrin protein that in humans is encoded by the ITGB7 gene. [5] [6] It can pair with ITGA4 (CD49d) to form the heterodimeric integrin receptor α 4 β 7, or with ITGAE (CD103) to form α E β 7. [7]

整联蛋白是由α链和β链组成的异二聚体整合膜蛋白。 编码的蛋白质与 alpha4 链或 alphaE 链形成二聚体，并在白细胞粘附中发挥作用。 与 alpha4 的二聚化形成了一个归巢受体，用于将淋巴细胞迁移到肠粘膜和淋巴结。 与 alphaE 的二聚化允许与配体上皮钙粘蛋白 (一种钙依赖性粘附分子) 结合。 交替剪接导致多个转录本变体。 已经描述了该基因的其他可变剪接转录变体，但它们的全长性质尚不清楚。 [RefSeq 提供，2013 年 9 月] This gene encodes a protein that is a member …

Integrin β7 (ITGB7), which is expressed on the surface of leukocytes, plays an essential role in the homing of immune cells to gut-associated lymphoid tissue and facilitating the retention of lymphocytes in gut epithelium; however, its role in colorectal cancer pathogenesis is …

2021年8月1日 · Integrin β7 (ITGB7), which is expressed on the surface of leukocytes, plays an essential role in the homing of immune cells to gut-associated lymphoid tissue and facilitating the retention of lymphocytes in gut epithelium; however, its role in colorectal cancer pathogenesis is poorly explored.

2022年3月30日 · Chromatin immunoprecipitation and gene-regulatory network analyses both defined Itgb7 as an LRF target. Our study identifies LRF as an essential transcriptional regulator of IELp maturation in...

Expression of integrin beta-7 is epigenetically enhanced in multiple myeloma subgroups with high-risk cytogenetics. Integrated analysis reveals the participation of IL4I1, ITGB7, and FUT7 in reshaping the TNBC immune microenvironment by targeting glycolysis.

2025年2月8日 · KLF3 acts as transcriptional repressor for the leukocyte-specific integrin beta7 (Itgb7, Ly69) by binding to the beta7 promoter, as revealed by chromatin immunoprecipitation. Mice lacking beta7 integrins in the innate immune compartment are more susceptible to intestinal inflammation, which is correlated with a requirement of beta7 integrins to ...

Predicted to be active in cell surface and focal adhesion. Orthologous to human ITGB7 (Integrin subunit beta 7). [provided by Alliance of Genome Resources, Apr 2022]

ITGB7 is a prognostic marker in Glioblastoma multiforme, Head and neck squamous cell carcinoma, Liver hepatocellular carcinoma, Ovary serous cystadenocarcinoma, Pancreatic adenocarcinoma Cancer specificity i