2024年9月1日 · 锝[99mTc]亚甲基二膦酸盐注射液(以下简称99mTc-MDP 注射液)是较理想的骨显 像剂,用于早期诊断恶性转移性骨肿瘤和原发性骨肿瘤,对移植骨的存活监测、 诊断外伤性骨折、骨骼炎症和代谢性骨病等均有重要价值[1-3]。

ITLC is a technique that has been developed to fill the need for a simple and rapid radiochemical analysis of radiopharmaceuticals in the clinical set­ ting. ITLC is the most commonly used and recommended method for mea­ surement of the radiochemical impurities 99mTc04 and …

2014年4月1日 · Silica gel-impregnated instant thin layer chromatography (ITLC-SG) strips have been in widespread use in the quality control of radiopharmaceuticals for over three decades (Saha, 2010). The major advantages of a validated ITLC analytical process have been the speed of the test and its relative simplicity and inexpense.

2018年11月1日 · Instant thin layer chromatographic (ITLC) assays were performed to determine whether the 99m Tc and MDP had formed a complex before encapsulation in the SLNs. ITLC assays of 99m Tc-MDP complex, 99m Tc-MDP solid lipid nanoparticles and technetium free MDP solid lipid nanoparticle compounds were run on Non-ultraviolet (UV) ITLC silica gel paper ...

结果：为了测量白蛋白纳米胶体、胶体锡、依美他嗪和琥珀酸的 rcp，gmcp-sa 是 itlc-sg 的合适替代品。 对于甲膦酸盐，GMCP-SA 适合测量胶体 99mTc 杂质，尽管产生的值略高于 ITLC-SG，但由于显着高估，不适合测量 99mTc 高锝酸盐杂质。

Radiochemical purity (RCP) is the proportion of the radioactivity which is present in the desired chemical form. It is sometimes called labelling efficiency.

There are numerous methods available to analyze technetium radiopharmaceuticals for radiochemical pu rity; however, instant thin layer chromatography (ITLC) is most frequently used because it is simple and rapid. Current ITLC methods are an outgrowth of systems used during the earlier days of Tc-99m radiopharma ceutical development.

2018年3月29日 · Radiochemical purity of labeled radiopharmaceutical was evaluated using instant thin layer chromatography (iTLC) strips from BIODEX Medical System Inc. (models 150-001 and 1500-005) with Acetone and distilled water as mobile phases.

The quality control of the RCP was performed using ITLC-SG chromatography, TLC (for 99m Tc-sestamibi) or filtration (for 99m Tc-albumin aggregated). Volume measurements of radiopharmaceuticals were taken using a validated precision pipette (RAININ Finpipette, U.S.A.) with a range of dispensation between 7 and 20 μl, while volumes of the ...

99mTc-亚甲基二膦酸盐简称99mTc-MDP，临用前，确保无菌条件。 按照99mTc洗脱液的放射性浓度，取4-6ml注入药盒，再抽取等体积的空气，震荡摇动，使冻干品溶解，在室温下静置5min。