Dec 25, 2024 · ITPK1 (Inositol-Tetrakisphosphate 1-Kinase) is a Protein Coding gene. Diseases associated with ITPK1 include Cerebral Falx Meningioma and Anterior Cranial Fossa Meningioma. Among its related pathways are Inositol phosphate metabolism and superpathway of D-myo-inositol (1,4,5)-trisphosphate metabolism.

Inositol (1,4,5) trisphosphate 3-kinase (EC 2.7.1.127), abbreviated here as ITP3K, is an enzyme that facilitates a phospho-group transfer from adenosine triphosphate to 1D-myo-inositol 1,4,5-trisphosphate.

Jan 12, 2010 · Independent of their enzymatic activity, ITPKs regulate the microstructure of the actin cytoskeleton. The immune phenotypes of ITPK knockout mice raise new questions about how ITPKs control inositol phosphate lifetimes within spatial and temporal domains during lymphocyte maturation.

Jan 29, 2008 · The enzyme ITPK1 (inositol 1,3,4-triphosphate 5/6 kinase) is the source of Ins (3,4,5,6)P 4. It can phosphorylate both Ins (1,3,4)P 3 at the 5 or 6 positions and Ins (3,4,5,6)P 4 at the 1 position and can also dephosphorylate Ins (1,3,4,5,6)P 5 to Ins (3,4,5,6)P 4.

Jan 1, 2021 · Inositol phosphate encompasses a large multifaceted family of signalling molecules that originate from the combinatorial attachment of phosphate groups to the inositol ring. To date, four distinct inositol kinases have been identified, namely, IPK, …

Jul 1, 2020 · Our results successfully established that RNAi-mediated silencing of OsITP5/6K-1 gene significantly reduced the phytate levels in seeds without hampering the germination potential of seeds and plant growth. The present study provided an insight into the mechanism of phytic acid biosynthesis pathway.

肌醇三/四磷酸激酶 (ITPK) 催化与肌醇磷酸和肌醇焦磷酸底物的多种磷酸转移反应。 然而，缺乏核苷酸协调的植物 ITPK 结构阻碍了对该家族磷酸转移反应的理性理解。

Mar 29, 2023 · Myo-inositol tris/tetrakisphosphate kinases (ITPKs) catalyze diverse phosphotransfer reactions with myo-inositol phosphate and myo-inositol pyrophosphate substrates. However, the lack of structures of nucleotide-coordinated plant ITPKs thwarts a rational understanding of phosphotransfer reactions of the family.

Jun 6, 2008 · We have cloned and characterized four Itpk genes from soybean. All four recombinant Itpk proteins showed canonical Ins (1,3,4)P 3 5/6-kinase activity, but a kinetic analysis raised questions about its biological significance.

有研究发现肌醇1，4，5-三磷酸3-激酶 (inositol 1，4，5-trisphosphate 3-kinase C， ITPKC)基因多态性在心血管系统疾病、消化系统疾病、妇科疾病、钙通道相关疾病易感性和发病方面可能有非常重要的作用。 该文将对近年关于 ITPKC 基因与相关疾病的研究进行综述。 引用本文: 孙蕙, 冯万禹, 王晓婷, 等. ITPKC 基因表达及在相关易感疾病的研究进展 [J] . 国际遗传学杂志, 2023, 46 (2) : 139-144. DOI: 10.3760/cma.j.cn231536-20221017-00096. 版权归中华医学会所有。 未经授 …