This orthogonally-protected lysine derivative is based on the hindered Dde variant ivDde.

The problem can be avoided for peptides containing side-chain modified lysine by using ivDde-Lys(Fmoc)-OH instead of Fmoc-Lys(ivDde)-OH for incorporation of those residues. The use of the former allows side-chain modification of lysine to be accomplished during chain extension.

Novel tool for the synthesis of branched, cyclic and modified peptides by Fmoc SPPS. Following introduction of this building block, the Fmoc group can be removed by treatment with piperidine in DMF enabling chain extension on the lysine side chain.

2017年4月26日 · Dmab/ivDde protecting groups avoid the use of heavy metal reagents during cleavage. The use of pre-prepared diaminodiacids has been established as an effective approach for the chemical synthesis of peptide disulfide bond mimics.

Fmoc-Lys(ivDde)-OH contains the iVDde group which can be orthogonally removed allowing for selective branching on the lysine side chain group.

Fmoc-Lys (IvDde)-OH | C34H42N2O6 | CID 135443653 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.

Fmoc-D-Lys (Ivdde)-OH | C34H42N2O6 | CID 135742620 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.

Fmoc-Lys(ivDde)-OH is an excellent choice for peptide synthesis where selective modification of the lysine side chain is required. It is a must-have reagent for researchers working on multi- functional peptides, cyclic peptides, or labeled peptides.

H-Lys(ivdde)-OH | C19H32N2O4 | CID 137123642 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.

1-(4,4-Dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl (ivDde), an amino protecting group cleavad by 2% hydrazine hydrate in DMF. ivDde is more stable towards the repetitive piperidine treatments during Fmoc-SPPS than Dde.