2022年6月2日 · JAK2 is a non-receptor tyrosine kinase that regulates hematopoiesis through the JAK-STAT pathway. The pseudokinase domain (JH2) is an important regulator of the activity …

哺乳动物有4个jak同源基因，包括jak1、jak2、jak3和tyk2 四个成员。 JAKs的分子量在120-140kDa之间，每个JAKs成员具有7个保守的JH结构域，无跨膜结构域 。 JAK的特征是双激酶 …

2024年3月8日 · JH2 was originally identified in JAK2 as a key regulator of activation that functions in a dualistic fashion; JH2 maintains JAKs in an inactive state in the absence of cytokine …

The JAK2 JH2 Pseudokinase Domain Inhibitor Screening Assay Kit is designed for screening and profiling small molecules that displace the fluorescently labeled probe (JH2 probe 1) from the …

Jak2 possesses a pseudokinase domain (JH2) and a tyrosine kinase domain (JH1). Through unknown mechanisms, JH2 regulates the catalytic activity of JH1, and hyperactivating …

JAK2 possesses a pseudokinase domain (JH2) and a tyrosine kinase domain (JH1). Through unknown mechanisms, JH2 regulates the catalytic activity of JH1, and hyperactivating …

2020年5月28日 · The present focus is on the discovery of molecules that may regulate the activity of JAK2 by selective binding to the JAK2 pseudokinase domain, JH2. Specifically, the …

Probe molecules that covalently modify the JAK2 pseudokinase domain (JH2) are reported. Selective targeting of JH2 domains over the kinase (JH1) domains is a necessary feature for …

6 天之前 · It downregulated JAK2 and STAT3 phosphorylation and stimulated autophagy in leukemic cells. In vivo, SAR317461 reduced peripheral blood leukocyte counts and prolonged …

Mutations in JH2 lead to increased JAK2 activity contributing to myeloproliferative neoplasms (MPNs). Here, we show that JH2 is a dual-specificity protein kinase that phosphorylates two …