Jul 29, 2012 · Our results resolve the ambiguity associated with the catalytic function of H3K27-specific JMJs in regulating disease-relevant inflammatory responses and provide encouragement for designing...

Mar 21, 2019 · Here, we identify an H3K27me3 demethylase, JUMONJI 13 (JMJ13), which regulates flowering time in Arabidopsis. Structural characterization of the JMJ13 catalytic domain in complex with its substrate...

Jun 17, 2021 · Trimethylation of histone H3 lysine 27 (H3K27me3) is a highly conserved repressive histone modification that signifies transcriptional repression in plants and animals. In Arabidopsis thaliana, the demethylation of H3K27 is regulated by a group of JUMONJI DOMAIN-CONTANING PROTEIN (JMJ) genes.

Apr 7, 2020 · Our results demonstrate that SlJMJ6 is a ripening-prompting H3K27me3 demethylase that activates the expression of the ripening-related genes by modulating H3K27me3, thereby facilitating tomato fruit ripening. Our work also reveals a novel link between histone demethylation and DNA demethylation in regulating fruit ripening.

Jun 9, 2021 · Here, we show that JUMONJI (JMJ) proteins, demethylases involved in histone H3 lysine 27 trimethylation (H3K27me3), are necessary for Arabidopsis thaliana heat acclimation. Acclimation induces...

Jun 16, 2021 · Trimethylation of histone H3 lysine 27 (H3K27me3) is a highly conserved repressive histone modification that signifies transcriptional repression in plants and animals. In Arabidopsis thaliana, the demethylation of H3K27 is regulated by a group of JUMONJI DOMAIN-CONTANING PROTEIN (JMJ) genes.

Jul 29, 2012 · 在这里，我们提出了一种结构引导的小分子和化学蛋白质组学方法来阐明 H3K27me3 特异性去甲基化酶亚家族（KDM6 亚家族成员 JMJD3 和 UTX）的功能作用。 人和小鼠 JMJD3 的配体结构为了解去甲基酶 KDM6 亚家族识别辅因子、底物和抑制剂的特异性决定因素提供了新的见解。 我们利用这些结构特征生成了第一个对 H3K27me3 特异性 JMJ 亚家族具有选择性的小分子催化位点抑制剂。 我们证明这种抑制剂以一种新的方式结合并减少脂多糖诱导的 …

Jul 31, 2024 · In this study, we identified SlJMJ3, a member of the KDM4/JHDM3 family, as an H3K27me3 demethylase in tomato (Solanum lycopersicum) that plays an important role in fruit ripening regulation. Overexpression of SlJMJ3 leads to accelerated fruit ripening, whereas loss of function of SlJMJ3 delays this process.

Jun 17, 2021 · Trimethylation of histone H3 lysine 27 (H3K27me3) is a highly conserved repressive histone modification that signifies transcriptional repression in plants and animals. In Arabidopsis thaliana, the...

Jul 14, 2023 · 组蛋白甲基化标记的生化测量显示，KGDH突变体中由JMJs催化的修饰包括H3K4me3、H3K9me2、H3K27me3和H3K36me3，其水平都显著下降了，而去甲基化由不需要α-KG的去甲基化酶LSDs催化的H3K4me1与H3K4me2、其水平没有明显变化。...