c-Jun N-terminal kinases - Wikipedia
The c-Jun N-terminal kinases consist of ten isoforms derived from three genes: JNK1 (four isoforms), JNK2 (four isoforms) and JNK3 (two isoforms). [2] Each gene is expressed as either …
JNK - 百度百科
JNK，（c-Jun 氨基末端 激酶，c-Jun N-terminal kinase）又被称为应激活化 蛋白激酶 (stress-activated protein kinase, SAPK)，是 哺乳类 细胞中 MAPK （mitogen -activated protein …
SAPK/JNK 信号级联放大 | Cell Signaling Technology
应激活化蛋白激酶 (SAPK)/Jun 氨基末端激酶 (JNK) 是 MAPK 家族的成员，可由各种不同环境应激、炎症细胞因子、生长因子以及 GPCR 激动剂激活。 应激反应信号经 Rho 家族（Rac、Rho …
c-Jun N-terminal kinase 2 suppresses pancreatic cancer growth …
2021年2月1日 · The c-Jun N-terminal protein kinases (JNKs) JNK1 and JNK2 can act as either tumor suppressors or pro-oncogenic kinases in human cancers.
Distinct roles for JNK1 and JNK2 in regulating JNK activity
2004年9月10日 · JNK2 is preferentially bound to c-Jun in unstimulated cells, thereby contributing to c-Jun degradation. In contrast, JNK1 becomes the major c-Jun interacting kinase after cell …
【AmBeed聚焦】深入剖析JNK信号通路：作用原理及抑制剂研究
2024年5月27日 · JNK家族共有三个JNK基因：JNK1、JNK2和JNK3，它们通过剪接产生异构体JNK1、JNK2和JNK3。 JNK3的表达局限于脑、心脏、睾丸、胰岛，JNK1和JNK2的表达无明 …
JNK2, a Newly-Identified SERCA2 Enhancer, Augments an ... - PubMed
2021年2月19日 · We have identified a novel JNK2-induced activation of SERCA2. The dual action of JNK2 in CaMKII-dependent arrhythmic SR Ca<sup>2+</sup> leak and a CaMKII …
JNK | c-Jun氨基末端激酶 | 抑制剂 | MCE - MCE-生物活性 ...
JNK (c-Jun N-terminal kinase), a kinase subfamily belonging to the MAPK, is activated in response to various stress stimuli and possess a wide variety of regulatory functions. The JNK …
The kinase Jnk2 promotes stress-induced mitophagy by targeting …
2015年3月23日 · Jnk2-deficient mice displayed defective mitophagy, which resulted in tissue damage under hypoxic stress, as well as hyperactivation of inflammasomes and increased …
c-Jun氨基末端激酶（JNK） - 百度
2024年8月1日 · JNK 信号通路可被细胞因子、生长因子、应激 ( 如电离辐射、渗透压、热休克和氧化损伤) 等多种因素激活，大量体外和活体实验均证实JNK与眼科疾病、慢性炎症、神经退行 …
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