2024年3月1日 · In this study, a folic acid (FA) decorated tumor-targeted nanocarrier for JQ1 was designed successfully, which showed outstanding performance in tumor targeting and indistinctive toxicity for the treatment of oral squamous cell carcinoma (OSCC).

2025年1月6日 · To address these challenges, the optimization of JQ1 delivery has been accomplished through polylactide (PLA) nanoparticles. PLA derivatives with varying molecular weights were synthesized via ring-opening polymerization using a zinc-based initiator and characterized using thermogravimetric analysis, differential scanning calorimetry, and ...

This study highlights the potential of PLA-derived NPs as advanced DDS for the BET inhibitor JQ1. By synthesizing PLA derivatives using a biocompatible Zn-based catalyst, we achieved high monomer conversion and controlled molecular weight.

2025年1月6日 · This study highlights the potential of PLA-derived NPs as advanced DDS for the BET inhibitor JQ1. By synthesizing PLA derivatives using a biocompatible Zn-based catalyst, we achieved high monomer conversion and controlled molecular weight.

2024年10月16日 · We developed a heterobifunctional small molecule, methylarginine targeting chimera (MrTAC), that recruits PRMT1 to a target protein for induced degradation in lysosomes. MrTAC compounds degraded...

因此，我们通过将jq1 [含溴结构域蛋白4（brd4）的小分子抑制剂]封装到叶酸（fa）修饰的纳米颗粒（peg- pla），可以延长jq1的半衰期并靶向肿瘤组织。 然后，从该纳米颗粒中释放的 JQ1 可以阻止 OSCC 的生长，从而诱导肿瘤细胞凋亡，抑制肿瘤血管生成和 M2 型巨噬 ...

2024年3月1日 · 这项研究提出了一种新的治疗oscc的策略，即通过将jq1封装到fa修饰的纳米粒子中，实现对肿瘤组织的靶向性。 此外，这种治疗方法还可以抑制肿瘤血管生成和M2型巨噬细胞的极化，从而达到更好的治疗效果。

2024年10月1日 · JQ1 is a wonder therapeutic molecule that selectively inhibits the BRD4 signaling pathway and is thus widely used in the anticancer drug discovery program. Due to its unique selective BRD4 binding property, its applications are further extended in the design and synthesis of bi-functional PROTAC molecules.

2025年1月8日 · 荷载紫杉醇与JQ1的PLGA纳米粒作为一种新型的抗肿瘤药物载体，具有提高药物溶解度、增强药物稳定性、降低药物副作用等优点。 本研究旨在制备荷载紫杉醇与JQ1的PLGA纳米粒，探究其制备工艺及其在抗肿瘤方面的应用。 二、材料与方法. 1. 材料. 紫杉醇、JQ1、聚乳酸-羟基乙酸共聚物（PLGA）、有机溶剂、抗肿瘤细胞株等。 2. 方法. （1）制备荷载紫杉醇与JQ1的PLGA纳米粒：采用乳化挥发法制备纳米粒，优化制备工艺，包括乳化剂种类、乳化温度、乳 …

2023年4月1日 · JQ1 inhibited the proliferation and induced apoptosis of GC cells in vitro. Besides, JQ1 suppressed the migration and invasion of cancer cells by inducing MET.