2013年10月1日 · During inflammation, several mediators directly or indirectly induce pain including pro-inflammatory cytokines and there is evidence that the JAK-STAT pathway is involved in the formation of pronociceptive cytokines. The same pathway, however, is also of importance for anti-inflammatory cytokines su …

Suppressor of cytokine signaling-1 (SOCS-1) is a molecule that can inhibit the activation of IL-4 signaling through the inhibition of JAKs. The Fes tyrosine kinase is activated by IL-4 and appears to be important in regulating IL-4-induced proliferation through the phosphorylation of insulin receptor substrate (IRS) molecules.

2022年11月14日 · JAK末端是一个羧基末端的催化或激酶结构域，前端是一个假激酶 (PK) 或激酶样结构域。 JAK通过氨基末端ezrin radixin、moesin (FERM)结构域和Src Homology 2 (SH2)结构域与细胞因子受体的Box1和Box2结构域结合。 直到最近才获得与细胞因子受体的细胞内结构域复合的 全长JAK1结构（图2）。 图2 Janus激酶的结构. STAT3 被鉴定为响应IL-6的DNA结合“急性期反应因子”。 表皮生长因子和其他生长因子也被认为是STAT3激活剂。 STAT4 主要在淋巴组 …

2000年3月20日 · The Fes kinase appears to act downstream of JAK to activate IRS molecules that are recruited to the activated IL-4 receptor complex. Pathways downstream of IRS, including PI3 kinase, are required for IL-4–induced proliferation.

IL-4R自身无激酶活性，其生物学功能主要通过 非受体型酪氨酸激酶JAK 激活。 IL-4R与配体结合后，使蛋白发生磷酸化，激活下游信号通路。 研究发现IL-4Rα、γc和IL-13Rα1分别激活JAK1、JAK2和Tyk2。 在免疫细胞中，IL4R信号通路会激活2种下游信号：IRS-PI3K-AKT途径和JAK-STAT6途径。 STAT6是转录因子，可被JAK进一步磷酸化，促进IL-4和IL-13转录表达。 IL-4Rα的表达与 乳腺癌肺转移 中STAT6、AKT和ERK活化增加有关，说明IL-4R信号通路及其下游蛋白 …

2001年1月1日 · In addition, we find that IL-4 and IL-13 each induce tyrosine phosphorylation of the JAK2 tyrosine kinase. Furthermore, both IL-4 and IL-13 induce binding of the Stat6 transcription factor to a consensus sequence oligonucleotide.

2024年7月22日 · Biological agents and small molecules have enriched the therapeutic armamentarium of moderate-to-severe AD, such as dupilumab, tralokinumab, lebrikizumab (monoclonal antibodies targeting the IL-4/13 pathway), …

2014年1月2日 · Several anti-inflammatory cytokines also signal via JAK-STAT including IL-4, which is one of the best known anti-inflammatory cytokines due to its widespread biological roles in diverse processes such as T-cell proliferation, activated B-cell stimulation, activation of macrophages, chronic inflammation, and wound repair.

2013年10月1日 · Current therapeutic approaches targeting molecules of the JAK-STAT signaling cascade are auspicious but as this review demonstrates, more experimental and clinical studies are required to...

Interleukin 4 (IL-4) was first identified as a factor that was produced by T cells and could enhance the proliferative response of B cells to anti-IgM and also was capable of inducible immunoglobulin (Ig) isotype switch of B cells to produce IgG, particularly IgG1 1, 2.