摘 要：连接黏附分子A (junctional adhesion molecule A, JAM-A) 属于免疫球蛋白超家族，是一种跨膜蛋白， 在胚胎发育、正常组织结构维持、炎症与免疫应答、创伤修复、肿瘤转移等多种生理病理过程中具有重要

JAM-1 regulates motility in epithelial cells by moderating expression of β1 integrin protein downstream of Rap1. JAM-1 has been shown to be able to cause cell adhesion, spreading and movement along β1 ligands, like collagen IV and fibronectin. [3] JAM-1 also acts to moderate migration of vitronectin in endothelial cells.

连接黏附分子 A (Junctional Adhesion Molecule A, JAM-A)，也称为 JAM-1，是一种跨膜蛋白，属于免疫球蛋白超家族，在调控紧密连接中起关键作用。 它具体位于上皮细胞和内皮细胞的紧密连接处，有助于维持连接完整性和通透性。

2024年12月25日 · F11R (F11 Receptor) is a Protein Coding gene. Diseases associated with F11R include Purulent Acute Otitis Media and Inflammatory Bowel Disease. Among its related pathways are Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling and Cell junction organization.

Junctional adhesion molecule 1 (JAM-1) was the first of a family of related proteins (JAM family) to be discovered. Two proteins with structural and sequence similarities to JAM-1, named JAM-2 and JAM-3, have been identified more recently. JAM-1 is specifically localized at the tight junctions of ep …

2002年1月14日 · We have identified the IgSF member junctional adhesion molecule 1 (JAM-1) as a ligand of the β 2 integrin lymphocyte function–associated antigen 1 (LFA-1). Under static and physiological...

2003年12月1日 · As expected, the JAM-1–depleted cells lacked bFGF-induced ERK signaling, which is required for bFGF-induced migration on vitronectin. These results confirm that JAM-1 is critical to both bFGF signaling and α v β 3 function in endothelial cells and place JAM-1 as a candidate target for therapeutic modulation.

Junctional adhesion molecules, JAM-1, -2, and -3, are a new subfamily in the immunoglobulin (Ig) superfamily that colocalize with these components of tight junctions. JAM-1 was identified through a screen of antibodies that recognizes antigens located at cell-cell contacts.

该综述简要总结了粘附分子家族 JAM（连接粘附分子）在各种细胞迁移中的作用，涵盖生殖细胞、上皮细胞、内皮细胞、几种白细胞和不同的癌细胞。 这些功能影响多种疾病，包括生殖疾病、炎症相关疾病、心血管疾病和癌症。 JAM 与相似和不同的蛋白质结合，并对不同的细胞产生相似和不同的影响。 得出相关结果，为进一步研究提供参考。

View credits, reviews, tracks and shop for the 1984 Vinyl release of "Scratchmasters Jam #1" on Discogs.