
JARID2 Gene - GeneCards | JARD2 Protein | JARD2 Antibody
2024年12月25日 · JARID2 (Jumonji And AT-Rich Interaction Domain Containing 2) is a Protein Coding gene. Diseases associated with JARID2 include Developmental Delay With Variable Intellectual Disability And Dysmorphic Facies and Non-Specific Syndromic Intellectual Disability .
JARID2 - Wikipedia
Jarid2 (jumonji, AT rich interactive domain 2) is a protein coding gene that functions as a putative transcription factor. Distinguished as a nuclear protein necessary for mouse embryogenesis, Jarid2 is a member of the jumonji family that contains a DNA binding domain known as the AT-rich interaction domain (ARID).
JARID2, a novel regulatory factor, promotes cell proliferation ...
JARID2 plays a crucial role in the binding of PRC2 to its target genes, leading to downregulation of gene expression through H3K27me3. It is highly expressed in various types of cancers, including breast cancer. JARID2 promotes glycolysis, lipid metabolism, proliferation, invasion, and stemness of breast cancer cells.
JARID2 and AEBP2 regulate PRC2 in the presence of H2AK119ub1 …
2021年1月22日 · JARID2 and AEBP2 each interact with one ubiquitin and the H2A-H2B surface. JARID2 stimulates PRC2 through interactions with both the polycomb protein EED and the H2AK119-ubiquitin, whereas AEBP2 has an additional scaffolding role.
JARID2 haploinsufficiency is associated with a clinically distinct ...
2020年10月20日 · JARID2, located on chromosome 6p22.3, is a regulator of histone methyltransferase complexes that is expressed in human neurons. So far, 13 individuals sharing clinical features including...
JARID2 jumonji and AT-rich interaction domain containing 2
JARID2 promotes stemness and cisplatin resistance in non-small cell lung cancer via upregulation of Notch1. JARID2 haploinsufficiency is associated with a clinically distinct neurodevelopmental syndrome. JARID2 and AEBP2 regulate PRC2 in the presence of …
Jarid2 is a PRC2 component in embryonic stem cells required
2010年5月16日 · Here we show that Jarid2 is a novel subunit of PRC2 that is required for the co-recruitment of PRC1 and RNAP to genes that regulate development in ES cells. Jarid2-deficient ES cells showed...
Entry - *601594 - JUMONJI, AT-RICH INTERACTIVE DOMAIN 2; JARID2 …
The JARID2 gene encodes a transcriptional repressor protein that regulates the activity of various histone methyltransferase complexes, affecting epigenetic changes that control gene expression during development, cellular differentiation, and morphogenesis (summary by Verberne et …
Jarid2 jumonji and AT-rich interaction domain containing 2
2025年2月8日 · Jarid2 is a novel player in iNKT cell maturation that regulates PLZF expression by modulating H3K9 methylation; Jarid2 is an important component of PRC2 that has a central role in coordinating hematopoietic stem and progenitor cell function
JARID2 regulates binding of the Polycomb repressive complex 2 ... - Nature
2010年1月14日 · Using genome-wide location analysis, we show that JARID2 binds to more than 90% of previously mapped PcG target genes. Notably, we show that JARID2 is sufficient to recruit PcG proteins to a...