Sep 7, 2020 · We show that sera and IgG from JEV-vaccinated humans and JEV-inoculated mice cross-reacted with ZIKV, exacerbated lethal ZIKV infection upon transfer to mice, and promoted viral replication and mortality upon ZIKV infection of the neonates born to immune mothers.

Sep 9, 2020 · Chen et al. show that Japanese encephalitis virus (JEV)–elicited CD8 + T cells and antibodies play protective and pathogenic roles in Zika virus–infected wild-type C57BL/6 mice, respectively, and JEV-elicited CD8 + T cells abrogate anti-JEV antibody–mediated enhancement of Zika virus infection in mice.

Feb 2, 2017 · Our data show that effector CD8 T cells play a protective role during primary infection possibly by preventing the breach in BBB and neuronal damage. Japanese encephalitis virus (JEV) commonly infects human beings in developing countries …

JEV infection dramatically enhanced the expression of programmed death 1 (PD-1) on infiltrating CD8 + T cells in the brain, as compared to that on peripheral CD8 + T cells in the spleen. This effect was more pronounced on infiltrating CCR2 + CD8 + T cells than on CCR2 - CD8 + T cells.

Aug 1, 2010 · In this study, we found that JEV induced the subversion of CD8(+) T cell responses in a transient manner that was closely correlated with viral multiplication. Subsequently, analysis using a TCR-transgenic system revealed that CD8(+) T cells purified from JEV-infected mice showed impaired responses, and that naive CD8(+) T cells adoptively ...

CD8 + T cells, which are crucial to the adaptive immune response, play an important role in managing JEV infections by directly destroying infected cells and producing antiviral substances. Adoptive transfer of virus-specific cytotoxic T lymphocytes (CTLs) provides significant protection against the fatal threats of JEV 16.

JEV infection resulted in extensive CD8 + T cell activation, judged by upregulation of surface markers CD69 and CD25 and cytokine production after stimulation with a JEV NS4B protein-derived H-2D b -binding peptide and trafficking of virus-immune CD8 + T cells into the CNS.

Healthy donors exposed to Japanese encephalitis (JE) virus show a CD8 + T cell response that cross reacts with other flaviviruses. Patients that recovered from JE show a CD4 + T cell response that targets structural proteins of JE virus.

Jul 1, 2024 · Recent findings by ourselves and other labs showed that JEV-elicited antibodies (Abs) and CD8 + T cells exacerbate and protect against subsequent ZIKV infection, respectively. However, the impact of JEV envelope (E) protein domain III (EDIII)-induced immune responses on ZIKV infection is unclear.

Jul 1, 2024 · Regarding adaptive immunity, JEV inhibits the maturation of dendritic cells and impairs their antigen-presenting function through the Toll-like receptor (TLR) pathway, thereby weakening CD8 + T-cell responses and promoting the proliferation of immunosuppressive regulatory T cells (Tregs) [6, 7].