2 天之前 · JMJD1A play roles in spermatogenesis, energy metabolism, regulation of stem cell as well as the initiation and progress of cancer. Here, we review the structure, catalytic mechanism, substrate specificity, biological function and inhibitor of JMJD1A. Key words: JMJD1A, Histone demethylase, Gene transcriptional regulation

2015年5月7日 · Histone 3 lysine 9 (H3K9) demethylase JMJD1A regulates β-adrenergic-induced systemic metabolism and body weight control. Here we show that JMJD1A is phosphorylated at S265 by protein kinase A...

2018年4月19日 · JMJD1A (also known as JHDM2A or KDM3A) is an histone H3 lysine 9 (H3K9) dimethyl and monomethyl (me2/1) demethylase, with broad functional roles in stem cell renewal 8, spermatogenesis 9, sex...

2015年5月7日 · Our results show that JMJD1A has two important roles in regulating hormone-stimulated chromatin dynamics that modulate thermogenesis in BATs. In one role, JMJD1A is recruited to target sites and functions as a cAMP-responsive scaffold that facilitates long-range chromatin interactions, and in the second role, JMJD1A demethylates H3K9 di ...

2021年9月3日 · We determined HIF-1α and Jumonji domain-containing protein 1 A (JMJD1A) expression by quantitative reverse transcription-polymerase chain reaction (qRT-PCR) and Western blot, analyzed inflammatory protein secretion in the cell supernatant by enzymelinked immunosorbent assay (ELISA), and assessed protein interaction between HIF-1α and JMJD1A ...

2022年1月12日 · JMJD1A (also called lysine demethylase 3A [KDM3A]) belongs to the Jumonji C family of histone demethylases. It specifically removes the repressive mono- or di-methyl marks from histone H3 at lysine 9 and thus contributes to the activation of gene transcription.

在这项研究中，我们在肾细胞和结肠癌细胞系中鉴定了依赖 jmjd1a 的缺氧诱导基因子集。 JMJD1A 通过降低启动子组蛋白甲基化来调节缺氧条件下肾上腺髓质素 (ADM) 和生长分化因子 15 (GDF15) 的表达。

2020年4月1日 · Here, we found that histone demethylase JMJD1A regulates expression of a different set of DDR genes largely through c-Myc. Inhibition of JMJD1A delayed the resolution of γ-H2AX foci, reduced the formation of foci containing ubiquitin, 53BP1, BRCA1 or Rad51, and inhibited the reporter activity of double-strand break (DSB) repair.

前列腺癌细胞中的异位 jmjd1a 表达促进体外增殖、迁移和侵袭，以及体内肿瘤发生；jmjd1a 击倒表现出相反的效果。 机械地，我们揭示了 JMJD1A 直接与 Snail 基因启动子相互作用并调节其转录活性，从而在体外和体内促进前列腺癌的进展。

2022年9月1日 · The JMJD1 subfamily includes JMJD1A, JMJD1B, and JMJD1C (or KDM3A, B, and C, respectively), which all contain 2 conserved domains required for catalytic activities, 25, 26 JmjC catalytic center,...