2024年12月25日 · JMJD1C (Jumonji Domain Containing 1C) is a Protein Coding gene. Diseases associated with JMJD1C include Angelman Syndrome and Central Nervous System Germinoma. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Golgi-to-ER retrograde transport.

Jumonji domain containing 1C is a protein that in humans is encoded by the JMJD1C gene. [5] The protein encoded by this gene interacts with thyroid hormone receptors and contains a jumonji domain. It is a candidate histone demethylase and is thought to be a coactivator for key transcription factors.

2024年2月14日 · Overall, this study identifies JMJD1C as an epigenetic hub that can integrate signals to establish tumor T reg cell fitness, and we present a specific JMJD1C inhibitor that can target tumor T...

2022年9月1日 · The JMJD1 subfamily includes JMJD1A, JMJD1B, and JMJD1C (or KDM3A, B, and C, respectively), which all contain 2 conserved domains required for catalytic activities, 25, 26 JmjC catalytic center,...

2022年8月23日 · Jmjd1c 是包含 JmjC 结构域的组蛋白去甲基化酶的成员，通过去除靶基因位点上的H3K9me2以促进基因转录，与白血病肿瘤发生、雄性配子发生和脂肪生成有关。

2024年2月15日 · 该研究揭示了JMJD1C作为肿瘤Treg适应性的关键表观遗传分子，通过协同抑制AKT和STAT3信号以实现TME中Treg细胞的适应性，并提供了一种特异性的靶点以选择性破坏肿瘤Treg细胞而不影响系统性免疫稳态，具有良好的应用前景。

2022年8月22日 · Here, we found that the expression of Jmjd1c, a member of JmjC domain histone demethylase, in B cells but not in other immune cells, protected mice from rheumatoid arthritis (RA). In humans with...

2025年2月9日 · JMJD1C is the autosomal gene where variants have been demonstrated to be associated with Testosterone (one of Cardiovascular disease risk factors) at genome-wide significance. Study provides evidence that SNPs of JMJD1C and KCNQ1 are prospectively associated with the risk of type 2 diabetes (T2D) in Korean population.

2024年11月6日 · 2024年10月25日，清华大学医学院 陈默 课题组于 Protein & Cell 杂志在线发表题为 JMJD1C forms condensates to facilitate a RUNX1-dependent gene expression program shared by multiple types of AML cells 的研究论文。 该研究 揭示了染色质因子JMJD1C如何协同造血关键转录因子RUNX1激活多亚型AML中关键基因的转录从而促进白血病细胞的生存以及增殖的机制。 该团队前期鉴定到一个染色质因子JMJD1C对于多种AML细胞的生存都是必需的。

JMJD1C deletion enhanced AKT signals in a manner dependent on histone H3 lysine 9 dimethylation (H3K9me2) demethylase and STAT3 signals independently of H3K9me2 demethylase, leading to robust interferon-γ production and tumor T reg cell fragility.