2013年5月15日 · KDM4/JMJD2 proteins are demethylases that target histone H3 on lysines 9 and 36 and histone H1.4 on lysine 26. This protein family consists of three ~130-kDa proteins …

2022年9月1日 · JMJD2 is one of the largest JMJD subfamilies and is comprised of JMJD2A-D proteins, also referred to as KDM4A-D. JMJD2 family members take active parts in multiple …

2011年5月9日 · JMJD2 proteins are lysine trimethyl–specific histone demethylases that catalyze the demethylation of trimethylated H3K9 (H3K9me3) and H3K36 (H3K36me3). Genome-wide …

2021年1月13日 · Histone demethylase JMJD2 (also known as KDM4) family proteins have been previously shown to support self-renewal and differentiation of stem cells. However, their roles …

KDM4/JMJD2 proteins are demethylases that target histone H3 on lysines 9 and 36 and histone H1.4 on lysine 26. This protein family consists of three ~130 kDa proteins (KDM4A–C) and …

Here we report studies on the inhibition of the JMJD2 subfamily of histone demethylases, employing binding analyses by nondenaturing mass spectrometry (MS), dynamic …

2006年5月5日 · We show the JmjC domain-containing protein JMJD2A reversed trimethylated H3-K9/K36 to di- but not mono- or unmethylated products. Overexpression of JMJD2A but not …

2019年10月3日 · KDM4/JMJD2 are H3K9- and H3K36-specific demethylases, which are considered promising therapeutic targets for the treatment of acute myeloid leukemia (AML) …

JMJD2B, also known as KDM4B, is a JmjC domain-containing histone demethylase belonged to the JMJD2 protein family. JMJD2B mainly targets the trimethyl of lysine 9 of histone H3 …

2019年10月3日 · KDM4 demethylases are required for sustained expression of genes important for survival of HSCs. KDM4/JMJD2 are H3K9- and H3K36-specific demethylases, which are …