JNK，（c-Jun氨基末端激酶，c-Jun N-terminal kinase）又被称为应激活化蛋白激酶(stress-activated protein kinase, SAPK)，是哺乳类细胞中MAPK（mitogen-activated protein kinase，丝裂原活化蛋白激酶）信号通路的另一亚类。

JNK 也称作 SAPKs（stress-activated protein kinases，应激激活的蛋白激酶），主要包括 JNK1（SAPKα，MAPK8）、JNK2（SAPKβ，MAPK9）、JNK3（SAPKγ，MAPK10）[1,3,5]。 JNK1、JNK2 在组织中广泛表达，而 JNK3 仅在脑、心和睾丸中表达 [2,5]。 JNK 磷酸化激活后可以作用下游多种转录因子（例如：Jun、Elk-1、Ets2等）与激酶（主要是MNK），产生促进生长、分化、存活、凋亡等多种生理效应 [1]。 活化的 JNK 能够磷酸化 c-Jun，其磷酸化位点位于 c …

2021年3月31日 · Here we found that the germinal ablation of the MAPK c-Jun N-Terminal Kinase isoform 1 (JNK1) results in a significant reduction of myelin in the cerebral cortex and corpus callosum at both...

JNK (c-Jun N-terminal kinase) is a member of the MAPK (mitogen-activated protein kinase) family that regulates a range of biological processes implicated in tumorigenesis and neurodegenerative disorders. For example, genetic studies have demonstrated that …

The JNK peptide inhibitor, D-JNKI-1 (XG-102) reversed these pathological events in the mitochondria and almost completely abolished cytochrome c release and PARP cleavage. Importantly, JNK3, but not JNK1 or JNK2, was associated with Bim in mitochondria and D-JNKI-1 prevented the formation of this apoptotic complex.

2002年2月1日 · The c-Jun NH 2-terminal kinase (JNK) is a member of an evolutionarily conserved sub-family of mitogen-activated protein (MAP) kinases. Recent studies have led to progress towards understanding the physiological function of the JNK signaling pathway, including the analysis of the phenotype of knockout mice.

D-JNKI-1 (AM-111; 10 μM) prevents nearly all hair cell death and permanent hearing loss induced by neomycin ototoxicity in the scala tympani of the guinea pig cochlea. Local delivery of D-JNKI-1 also prevents acoustic trauma-induced permanent hearing loss in a dose-dependent manner.

2024年8月1日 · c-Jun氨基末端激酶（c-Jun N-terminal kinase，JNK）家族是促分裂活化蛋白激酶（MAPK）超家族的成员之一。 JNK 信号通路可被细胞因子、生长因子、应激( 如电离辐射、渗透压、热休克和氧化损伤) 等多种因素激活，大量体外和活体实验均证实JNK与眼科疾病、慢性炎症 ...

JNK小鼠单克隆抗体（D-2）可识别JNK免疫原序列中的表位，并表现出广泛的物种交叉反应性，可通过蛋白质印迹（WB）、免疫沉淀（IP）、流式细胞术（FCM）和酶联免疫吸附测定（ELISA）检测小鼠、大鼠和人类样本中的JNK蛋白。 抗JNK单克隆抗体（D-2）有非结合型和多种结合型，包括琼脂糖、辣根过氧化物酶（HRP）、藻红蛋白（PE）、异硫氰酸荧光素（FITC）和各种Alexa Fluor®结合物，可满足各种实验需求。 JNK蛋白（也称为MAPK8/9/10 …

2019年5月9日 · JNK mouse monoclonal antibody (D-2) recognizes an epitope within the JNK immunogen sequence and demonstrates broad species cross-reactivity, detecting JNK proteins in mouse, rat, and human samples through Western blotting (WB), immunoprecipitation (IP), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA) applications.