c-Jun N-terminal kinase (JNK) mediates feedback inhibition of the ...
2003年1月31日 · Activation of the c-Jun N-terminal kinase (JNK) by proinflammatory cytokines inhibits insulin signaling, at least in part, by stimulating phosphorylation of rat/mouse insulin …
The Role of JNk Signaling Pathway in Obesity-Driven Insulin …
Chronic low-grade inflammation and FFA induced by obesity can activate JNK to phosphorylate insulin receptor substrates (IRS) 1 and 2 at Ser/Thr residues 18 and dephosphorylate IRS-1 …
The c-Jun NH - Journal of Biological Chemistry
Serine 307 is a major site of JNK phosphorylation in IRS-1. Mutation of serine 307 to alanine eliminates phosphorylation of IRS-1 by JNK and abrogates the inhibitory effect of TNFα on …
Endoplasmic reticulum stress mediates JNK-dependent IRS-1 …
2016年8月10日 · Our results demonstrated that Aβ 1–42 oligomers significantly induced ERS and JNK activation. In addition, in response to Aβ 1–42 oligomers, IRS-1 phosphorylation at …
The c-Jun NH2-terminal Kinase Promotes Insulin Resistance during ...
2000年3月24日 · Serine 307 is a major site of JNK phosphorylation in IRS-1. Mutation of serine 307 to alanine eliminates phosphorylation of IRS-1 by JNK and abrogates the inhibitory effect …
Endoplasmic reticulum stress mediates JNK-dependent IRS-1 …
2016年8月10日 · In peripheral insulin signaling impairment, ERS interferes with insulin signaling through c-Jun. N-terminal kinase (JNK)-dependent insulin receptor substance-1 (IRS-1) serine …
JNK通过抑制胰岛素信号通路介导了高糖和软脂酸诱导的胰岛β细胞 …
2011年2月13日 · 有研究证实，FFA和各类炎症因子如TNF-α 诱导了JNK的激活，提高了IRS-1 上丝氨酸磷酸化水平，从而减弱了胰岛素靶组织如肝脏和脂肪中胰岛素信号通路
内质网应激介导JNK依赖的IRS-1丝氨酸磷酸化，并导致淀粉样β寡 …
N末端激酶（JNK）依赖性胰岛素受体物质1（IRS-1）丝氨酸磷酸化。 我们进行了这项研究，以确定是否类似的机制有助于AD发病机制中的胰岛素信号传导障碍。
The c-Jun NH(2)-terminal kinase promotes insulin resistance …
2000年3月24日 · TNFalpha promotes multipotential signal transduction cascades, including the activation of the Jun NH (2)-terminal kinase (JNK). Endogenous JNK associates with IRS-1 in …
胰岛素信号转导通路 | Cell Signaling Technology
胰岛素激活胰岛素受体 (IR) 酪氨酸激酶，后者能够聚集并磷酸化各种底物对接蛋白，例如胰岛素受体底物 (IRS) 蛋白家族。 酪氨酸磷酸化的 IRS 会暴露出结合位点，供众多信号转导伴侣结合 …
- 某些结果已被删除