Distinct Roles for JNK and IKK Activation in Agouti-Related …
2014年11月20日 · JNK activation increases spontaneous action potential firing of AgRP cells and causes both neuronal and systemic leptin resistance. Similarly, activation of IKK2 signaling in AgRP neurons also increases firing of these cells but fails to cause obesity and leptin resistance.
A central role of IKK2 and TPL2 in JNK activation and viral B-cell ...
2020年2月4日 · Here we identify a novel and critical function of IKK2 and its co-factor NEMO in the activation of oncogenic c-Jun N-terminal kinase (JNK) signaling, induced by the latent membrane protein 1...
TAK1 is a ubiquitin-dependent kinase of MKK and IKK - Nature
2001年7月19日 · TRAF6 is a signal transducer that activates IκB kinase (IKK) and Jun amino-terminal kinase (JNK) in response to pro-inflammatory mediators such as interleukin-1 (IL-1) and...
Pathway干货 | NF-Kb 信号通路简介 - 知乎 - 知乎专栏
通过nemo的寡聚化或泛素化依赖机制直接介导ikk复合物的激活。 TAK1和NIK作为IKK激酶出现在NF-κB信号通路中。 其中，在经典信号通路中， TAK1被涉及。
JNK2 and IKKβ Are Required for Activating the Innate Response to …
1999年12月1日 · Both IKKβ and JNK2 are essential for efficient induction of type I IFN and other cytokines in response to viral infection or dsRNA. This study establishes a general role for these kinases in activation of innate immune responses.
IKK - 百度百科
IKK（inhibitor of kappa B kinase, kappa B 抑制因子激酶）参与胞内多种细胞信号转导途径，包括由细胞因子引起的细胞凋亡,其中最为人熟知的是可以通过磷酸化细胞质基质中与NF-κB【p65-p50二元复合体蛋白】结合的IκBα蛋白，使其得以被E3泛素连接酶特异性识别并添加 ...
Muscle Cell Palmitate-Induced Insulin Resistance, JNK, IKK/NF-κB …
Increased blood free fatty acids (FFAs), often observed in obesity, leads to impaired insulin action, and promotes the development of insulin resistance and Type 2 diabetes mellitus (T2DM). JNK, IKK-NF-κB, and STAT3 are known to be involved in skeletal muscle insulin resistance.
IKK Biology - PMC
The inhibitor of nuclear factor-κB (IκB) kinase (IKK) complex is the master regulator of the NF-κB signaling pathway. The activation of the IKK complex is a tightly regulated, highly stimulus-specific, and target-specific event that is essential for ...
Distinct Roles for JNK and IKK Activation in Agouti-Related …
2014年11月20日 · The data reveal distinct effects of c-Jun N-terminal kinase (JNK)- and inhibitor of nuclear factor kappa-B kinase (IKK)-dependent signaling in AgRP neurons, which cooperate in the manifestation of the metabolic syndrome.
TAK1 is a ubiquitin-dependent kinase of MKK and IKK - PubMed
2001年7月19日 · TRAF6 is a signal transducer that activates IkappaB kinase (IKK) and Jun amino-terminal kinase (JNK) in response to pro-inflammatory mediators such as interleukin-1 (IL-1) and lipopolysaccharides (LPS). IKK activation by TRAF6 requires two intermediary factors, TRAF6-regulated IKK activator 1 (TRIKA …