2017年2月8日 · Overproduction of PPM1A suppressed apoptosis of Mtb- infected macrophages by a mechanism that involves inactivation of the c-Jun N-terminal kinase (JNK). Targeted …

2015年2月2日 · Here we found that PtpA suppressed innate immunity dependent on pathways of the kinases Jnk and p38 and the transcription factor NF-κB by exploiting host ubiquitin. …

2023年11月28日 · We demonstrate that Mtb infection results in muted phosphorylation of p38 and JNK, regulators of inflammation, and leverage our single-cell methods to distinguish between …

2012年5月5日 · Enhanced intracellular survival (Eis) protein, secreted by Mtb, enhances survival of Mycobacterium smegmatis ( Msm) in macrophages. Mtb Eis was shown to suppress host …

2019年1月1日 · Mtb AcpM significantly decreased apoptosis/necrosis and enhanced intracellular bacterial survival by modulating ROS generation and the JNK signaling pathway. These …

2012年5月15日 · We propose that Mtb Eis initiates the inhibition of JNK-dependent autophagy, phagosome maturation, and ROS generation by acetylating DUSP16/MKP-7. Our work thus …

2018年4月15日 · PtkA programs macrophage through MEK-JNK-cJUN pathway. Mycobacterium tuberculosis (MTB) is a successful pathogen which increases persistence inside the host …

Leukotactin (Lkn)-1 is a CC chemokine and is upregulated in macrophages in response to Mycobacterium tuberculosis (MTB) infection. We investigated whether mitogen-activated …

2017年2月8日 · PPM1A 的过量产生通过涉及 c-Jun N 末端激酶 (JNK) 失活的机制抑制了 Mtb 感染的巨噬细胞的凋亡。 通过 shRNA 靶向消除 PPM1A 或通过血 根碱抑制 PPM1A 活性可恢复 …

2012年4月7日 · At home on inspection I found the rocker bearing was broken in half, it is Jnk (japan) bearing. Bike is only three days old, taking it back for free repair ! Any suggestions for …