ROS-dependent activation of JNK converts p53 into an efficient ... - PubMed
ROS promote the activation of c-Jun N-terminal kinase (JNK) and DNA damage response, which establishes a positive feedback loop with p53. This converts the p53-induced growth …
ROS-dependent activation of JNK converts p53 into an efficient …
2014年1月10日 · ROS promote the activation of c-Jun N-terminal kinase (JNK) and DNA damage response, which establishes a positive feedback loop with p53. This converts the p53-induced …
MEKK1/JNK signaling stabilizes and activates p53 - PMC
Activation of the tumor suppressor p53 by stress and damage stimuli often correlates with induction of stress kinases, Jun-NH2 kinase (JNK). As JNK association with p53 plays an …
Role of JNK activation in apoptosis: A double-edged sword
2005年1月1日 · The anti-apoptotic function of JNK may be related to the status of p53 since JNKAS inhibited growth of certain p53-deficient, but not p53 positive, tumor cells 55.
JNK targets p53 ubiquitination and degradation in nonstressed cells
1998年9月9日 · In this study we elucidated the role of nonactive JNK in regulating p53 stability. The amount of p53–JNK complex was inversely correlated with p53 level. A peptide …
Targeting p53 via JNK Pathway: A Novel Role of RITA for …
2012年1月20日 · Our study unveils a previously undescribed mechanism of RITA-induced p53-mediated apoptosis through JNK signaling pathway and provides the rationale for combination …
JNK confers 5-fluorouracil resistance in p53-deficient and mutant p53 …
2014年4月15日 · Here we report that 5-FU treatment causes aberrant autophagosome accumulation in HCT116 p53 (-/-) and HT-29 cancer cells. Specific inhibition of autophagy by 3 …
c-Jun N-terminal kinase 1/P53 signaling mediates ... - ScienceDirect
2024年10月15日 · As downstream of intracellular enzyme JNK, c-Jun negatively regulates the transcription of p53 through the transcription factor AP-1 during cell cycle progression …
Mutant and wild-type p53 form complexes with p73 upon
2018年4月3日 · We found that JNK-mediated phosphorylation of Thr 81 in the proline-rich domain (PRD) of p53 enabled wild-type p53, as well as mutant p53, to form a complex with p73. …
ROS-dependent activation of JNK converts p53 into an efficient ...
The activation of MAP kinase JNK upon inhibition of TrxR 29 and its ability to modulate p53 make JNK an attractive candidate mediator of ROS signaling to p53. We found that RITA induced …