2014年1月9日 · In this paper, we have identified that P-JNK interaction with Sab is a key event in the perturbation of mitochondrial ATP producing respiration in tunicamycin or BFA-induced ER stress and has a...

2015年2月15日 · We have reported that the interaction of JNK with mitochondrial Sab leads to inhibition of respiration, increased reactive oxygen species (ROS), cell death and hepatotoxicity. We tested whether this pathway underlies palmitic acid (PA)-induced lipotoxicity in hepatocytes.

Sustained JNK activation by saturated fatty acids plays a role in lipotoxicity and the pathogenesis of NASH. We have reported that the interaction of JNK with mitochondrial Sab leads to inhibition of respiration, increased ROS, cell death and ...

Our findings have identified a link between the interaction of P-JNK and Sab and inhibition intramitochondrial Src leading to inhibition of mitochondrial respiration in the promotion of cell death and organ injury. All animal experiments followed procedures approved by the IACUC of the University of Southern California.

2024年3月14日 · We discuss here the mechanism and modulators of the JNK-SAB-ROS activation loop, which is the core component of mitochondria-dependent cell death, specifically apoptosis and mitochondrial permeability transition (MPT)-driven necrosis, and which may also contribute to cell death mechanisms of ferroptosis and pyroptosis.

磷酸化 JNK (p-JNK) 与线粒体外膜 SH3 同源相关的 BTK 结合蛋白（Sab 或 SH3BP5）相互作用。使用敲除或肝脏特异性 Sab 缺失，我们旨在阐明这种相互作用对体内分离线粒体和肝损伤模型中线粒体功能的影响。p-JNK + 三磷酸腺苷直接抑制分离线粒体的呼吸。

Phosphorylated JNK (p-JNK) interacts with the mitochondrial outer membrane SH3 homology associated BTK binding protein (Sab, or SH3BP5). Using knockdown or liver-specific deletion of Sab, we aimed to elucidate the consequences of this interaction on mitochondrial function in isolated mitochondria and liver injury models in vivo.

2005年1月1日 · The binding of JNK to Sab further impairs mitochondrial respiration and enhances mitochondrial ROS generation by activating a signaling cascade involving mitochondrial protein tyrosine...

2024年1月1日 · 一篇最新的论文发现了JNKs和线粒体蛋白SAB相互作用，参与了细胞死亡过程的信号调节。 这一发现使我们更好地理解了细胞死亡的机制和持续激活JNK（P-JNK）的过程。 论文还探讨了JNK-SAB-ROS激活环路的机制和调节因子，这是线粒体依赖性细胞死亡的核心组成部分，特别是凋亡和线粒体通透性转换（MPT）驱动的坏死，并可能有助于铁死和火死的细胞死亡机制。 虽然这篇论文的讨论基于肝脏疾病模型的结果和证据，但JNK-SAB-ROS激活环路以维 …

2022年5月3日 · Whether mitochondrial dysfunction induced by the JNK/Sab signaling pathway plays a pivotal role in the lipotoxic injury of nonalcoholic steatohepatitis (NASH) remains a lack of evidence. Scoparone, a natural compound from Traditional Chinese Medicine herbs, has the potential for liver protection and lipid metabolism regulation.